ArticleNature communications2019
Propagation of temporal and rate signals in cultured multilayer networks.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Patterned pre-sensory spontaneous activity drives the structural refinement of developing cochlear ribbon synapses.Frontiers in synaptic neuroscience · 2026Article
- Closed-loop rehabilitation of upper-limb dyskinesia after stroke: from natural motion to neuronal microfluidics.Journal of neuroengineering and rehabilitation · 2025Review
- Arbor-TVB: a novel multi-scale co-simulation framework with a case study on neural-level seizure generation and whole-brain propagation.Frontiers in computational neuroscience · 2025Article
- Synaptic plasticity: from chimera states to synchronicity oscillations in multilayer neural networks.Cognitive neurodynamics · 2024Article
- Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics.Nature communications · 2024Article
- Network Bursts in 3D Neuron Clusters Cultured on Microcontact-Printed Substrates.Micromachines · 2023Article
- Article
- An Overview of In Vitro Biological Neural Networks for Robot Intelligence.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Microfluidics for Neuronal Cell and Circuit Engineering.Chemical reviews · 2022Review
- Mathematical framework for place coding in the auditory system.PLoS computational biology · 2021Article
- Induction and propagation of transient synchronous activity in neural networks endowed with short-term plasticity.Cognitive neurodynamics · 2021Article
- Necessary Conditions for Reliable Propagation of Slowly Time-Varying Firing Rate.Frontiers in computational neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Analyses of idealized feedforward networks suggest that several conditions have to be satisfied in order for activity to propagate faithfully across layers. Verifying these concepts experimentally has been difficult owing to the vast number of variables that must be controlled. Here, we cultured cortical neurons in a chamber with sequentially connected compartments, optogenetically stimulated individual neurons in the first layer with high spatiotemporal resolution, and then monitored the subthreshold and suprathreshold potentials in subsequent layers. Brief stimuli delivered to the first layer evoked a short-latency transient response followed by sustained activity. Rate signals, carried by the sustained component, propagated reliably through 4 layers, unlike idealized feedforward networks, which tended strongly towards synchrony. Moreover, temporal jitter in the stimulus was transformed into a rate code and transmitted to the last layer. This novel mode of propagation occurred in the balanced excitatory-inhibitory regime and is mediated by NMDA-mediated receptors and recurrent activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.