Evidence map›Paper›PMID 31481660›Full record

ArticleScientific reports2019

Nucleoporin insufficiency disrupts a pluripotent regulatory circuit in a pro-arrhythmogenic stem cell line.

Claudia C Preston, Emily C Storm, Ryan D Burdine, Tyler A Bradley, Andrew D Uttecht, Randolph S Faustino

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Nucleoporins in cardiovascular disease.Journal of molecular and cellular cardiology · 2020
    Review
  9. Protein Subdomain Enrichment ofFrontiers in cardiovascular medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Claudia C PrestonGenetics and Genomics Group, Sanford Research, 2301 E. 60th Street N., Sioux Falls, SD, 57104, USA.ORCID http://orcid.org/0000-0002-8067-6785
Emily C StormGenetics and Genomics Group, Sanford Research, 2301 E. 60th Street N., Sioux Falls, SD, 57104, USA.
Ryan D BurdineGenetics and Genomics Group, Sanford Research, 2301 E. 60th Street N., Sioux Falls, SD, 57104, USA.
Tyler A BradleyGenetics and Genomics Group, Sanford Research, 2301 E. 60th Street N., Sioux Falls, SD, 57104, USA.
Andrew D UttechtGenetics and Genomics Group, Sanford Research, 2301 E. 60th Street N., Sioux Falls, SD, 57104, USA.
Randolph S FaustinoGenetics and Genomics Group, Sanford Research, 2301 E. 60th Street N., Sioux Falls, SD, 57104, USA. Randolph.Faustino@SanfordHealth.org.
Sanford Research · USSanford Health · US

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
NIGMS NIH HHS P20 GM103620
6 · The paper itself

Abstract

Nucleoporins have been reported to regulate pluripotent biology, but how they do so remains partially characterized. This study examined the effects of nup155 gene disruption on mouse embryonic stem cells to gain insights into possible mechanisms by which nucleoporins regulate pluripotency in a pro-arrhythmogenic stem cell line. Embryonic stem cells with gene-trapped nup155 exhibited aberrant colony morphology underscored by abnormal transcriptome remodeling. Bioinformatic analysis of whole transcriptome data from nup155

Indexed as

AllelesAnimalsCell LineDown-RegulationEmbryonic Stem CellsMiceMicroRNAsNanog Homeobox ProteinNuclear Pore Complex ProteinsOctamer Transcription Factor-3Pluripotent Stem CellsRNA, UntranslatedSOXB1 Transcription FactorsTranscriptomeMicroRNAsNanog Homeobox ProteinNuclear Pore Complex ProteinsNUP155 protein, mouseOctamer Transcription Factor-3RNA, UntranslatedSOXB1 Transcription Factors

Identifiers

PMID31481660
PMCPMC6722237
OpenAlexW2971857891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.