Evidence map›Paper›PMID 31481610›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.

Yifeng Yuan, Rémi Zallot, Tyler L Grove, Daniel J Payan, Isabelle Martin-Verstraete, Sara Šepić, Seetharamsingh Balamkundu, Ramesh Neelakandan, Vinod K Gadi, Chuan-Fa Liu and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 63 citations in OpenAlex.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The current riboswitch landscape inMicrobiology (Reading, England) · 2024
    Review
  13. Queuosine salvage inMicrobiology (Reading, England) · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Queuosine Salvage inbioRxiv : the preprint server for biology · 2024
    Article
  19. Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Yifeng YuanDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611.
Rémi ZallotInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Tyler L GroveDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Daniel J PayanInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Isabelle Martin-VerstraeteLaboratoire de Pathogénèse des Bactéries Anaérobies, Institut Pasteur et Université de Paris, F-75015 Paris, France.
Sara ŠepićDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611.
Seetharamsingh BalamkunduSingapore-MIT Alliance for Research and Technology, Infectious Disease Interdisciplinary Research Group, 138602 Singapore, Singapore.
Ramesh NeelakandanSingapore-MIT Alliance for Research and Technology, Infectious Disease Interdisciplinary Research Group, 138602 Singapore, Singapore.
Vinod K GadiSingapore-MIT Alliance for Research and Technology, Infectious Disease Interdisciplinary Research Group, 138602 Singapore, Singapore.
Chuan-Fa LiuSingapore-MIT Alliance for Research and Technology, Infectious Disease Interdisciplinary Research Group, 138602 Singapore, Singapore.
Manal A SwairjoDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182.
Peter C DedonSingapore-MIT Alliance for Research and Technology, Infectious Disease Interdisciplinary Research Group, 138602 Singapore, Singapore.
Steven C AlmoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
John A GerltInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Valérie de Crécy-LagardDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611; vcrecy@ufl.edu.
Singapore-MIT Alliance for Research and Technology · SGUniversity of Florida · USUniversity of Illinois Urbana-Champaign · USAlbert Einstein College of Medicine · USCenter for Environmental Health · USInstitut Pasteur · FRSan Diego State University · US

Funding

Core H: MicrobiologyU54GM093342 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI JACOBSON, MATTHEW P · 2010 to 2015
$34.6M
The NYSGRC: A Large Scale Center for PSI:BiologyU54GM094662 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMO, STEVEN C. · 2010 to 2014
$32.6M
Protein/Structure CoreP01GM118303 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GERLT, JOHN A · 2016 to 2020
$11.4M
Synthesis and function of Queuosine in BacteriaR01GM070641 · NIGMS · UNIVERSITY OF FLORIDA · PI DE CRECY-LAGARD, VALERIE A · 2006 to 2023
$5.3M
RNA modification: Structure and MechanismR01GM110588 · NIGMS · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI SWAIRJO, MANAL A · 2014 to 2024
$3.9M
An integrated X-ray data collection systemS10OD020068 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMO, STEVEN C. · 2015 to 2015
$600k
Function and Mechanism of Viperin, a radical SAM antiviral proteinR21AI133329 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMO, STEVEN C., GROVE, TYLER L · 2017 to 2018
$459k
NIAID NIH HHS R21 AI133329NIGMS NIH HHS P01 GM118303NIGMS NIH HHS R01 GM070641NIGMS NIH HHS R01 GM110588NIGMS NIH HHS U54 GM093342NIGMS NIH HHS U54 GM094662NIH HHS S10 OD020068
6 · The paper itself

Abstract

Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a Q precursor. While many bacteria are capable of Q de novo synthesis, salvage of the prokaryotic Q precursors preQ

Indexed as

Bacterial ProteinsChlamydia InfectionsChlamydia trachomatisClostridioides difficileClostridium InfectionsGuanineHumansPentosyltransferasesRNA, TransferSignal TransductionSubstrate SpecificityBacterial ProteinsGuaninePentosyltransferasesqueuinequeuine tRNA-ribosyltransferaseRNA, Transfercomparative genomicsnucleoside transportqueuosinerSAMsequence similarity network

Identifiers

PMID31481610
PMCPMC6754566
OpenAlexW2971796559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.