Evidence map›Paper›PMID 31481582›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

Noninvasive PET Imaging of CDK4/6 Activation in Breast Cancer.

Nicholas Ramos, Jairo Baquero-Buitrago, Zakia Ben Youss Gironda, Youssef Zaim Wadghiri, Thomas Reiner, Fernando E Boada, Giuseppe Carlucci

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. New Radiopharmaceutical Tracers in Breast Cancer Diagnosis and Therapy.Anti-cancer agents in medicinal chemistry · 2025
    Review
  3. Article
  4. Synthesis and Preclinical Evaluation of NovelACS medicinal chemistry letters · 2024
    Article
  5. Engineering small-molecule and protein drugs for targeting bone tumors.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. The G1 phase optical reporter serves as a sensor of CDK4/6 inhibitionInternational journal of biological sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nicholas RamosCenter for Advanced Imaging Innovation and Research (CAIR), NYU School of Medicine, New York, New York; Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, New York.
Jairo Baquero-BuitragoCenter for Advanced Imaging Innovation and Research (CAIR), NYU School of Medicine, New York, New York; Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, New York.
Zakia Ben Youss GirondaCenter for Advanced Imaging Innovation and Research (CAIR), NYU School of Medicine, New York, New York; Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, New York.
Youssef Zaim WadghiriCenter for Advanced Imaging Innovation and Research (CAIR), NYU School of Medicine, New York, New York; Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, New York.
Thomas ReinerDepartment of Radiology, Weill Cornell Medical College, New York, New York.
Fernando E BoadaCenter for Advanced Imaging Innovation and Research (CAIR), NYU School of Medicine, New York, New York; Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, New York.
Giuseppe CarlucciCenter for Advanced Imaging Innovation and Research (CAIR), NYU School of Medicine, New York, New York; Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, New York giuseppe.carlucci@nyulangone.org.
Advanced Imaging Research (United States) · USNew York University · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204441NIBIB NIH HHS P41 EB017183
6 · The paper itself

Abstract

The cell cycle is a progression of 4 distinct phases (G1, S, G2, and M), with various cycle proteins being essential in regulating this process. We aimed to develop a radiolabeled cyclin-dependent kinase 4/6 (CDK4/6) inhibitor for breast cancer imaging. Our transfluorinated analog (

Indexed as

AnimalsBiological TransportBreast NeoplasmsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Enzyme ActivationFemaleFluorine RadioisotopesHalf-LifeHumansIsotope LabelingMCF-7 CellsMicePositron-Emission TomographyProtein Kinase InhibitorsRadiochemistryCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Fluorine-18Fluorine RadioisotopesProtein Kinase Inhibitorsbreast cancerCDK4/6cell cycleMCF-7PET/CT imaging

Identifiers

PMID31481582
PMCPMC9374032
OpenAlexW2971492200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.