Evidence map›Paper›PMID 31481575›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye-Protein Interaction.

Albertus W Hensbergen, Tessa Buckle, Danny M van Willigen, Margret Schottelius, Mick M Welling, Felicia A van der Wijk, Tobias Maurer, Henk G van der Poel, Gabri van der Pluijm, Wytske M van Weerden and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 56 citations in OpenAlex.

  1. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
    Review
  2. Review
  3. Article
  4. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Lessons learned in application driven imaging agent design for image-guided surgery.European journal of nuclear medicine and molecular imaging · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Robot-Assisted Prostate-Specific Membrane Antigen-Radioguided Surgery in Primary Diagnosed Prostate Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  17. Precision Surgery Guided by Intraoperative Molecular Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Albertus W HensbergenInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Tessa BuckleInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Danny M van WilligenInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Margret SchotteliusPharmazeutische Radiochemie, Technische Universität München, Garching, Germany.
Mick M WellingInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Felicia A van der WijkInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Tobias MaurerMartini-Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Henk G van der PoelDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Gabri van der PluijmDepartment of Urology, Leiden University Medical Centre, Leiden, The Netherlands; and.
Wytske M van WeerdenDepartment of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hans-Jürgen WesterPharmazeutische Radiochemie, Technische Universität München, Garching, Germany.
Fijs W B van LeeuwenInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands f.w.b.van_leeuwen@lumc.nl.
Leiden University Medical Center · NLTechnical University of Munich · DEErasmus MC Cancer Institute · NLLeiden University · NLThe Netherlands Cancer Institute · NLUniversity Medical Center Hamburg-Eppendorf · DE

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Prostate cancer surgery is currently being revolutionized by the use of prostate-specific membrane antigen (PSMA)-targeted radiotracers, for example,

Indexed as

AnimalsAntigens, SurfaceCarbocyaninesCell Line, TumorCell Transformation, NeoplasticColoring AgentsGlutamate Carboxypeptidase IIHumansMiceRadioactive TracersTissue DistributionTomography, Emission-Computed, Single-PhotonAntigens, SurfaceCarbocyaninesColoring AgentsFOLH1 protein, humanGlutamate Carboxypeptidase IIRadioactive Tracerscyaninehybrid tracersimage-guided surgeryprostate cancerprostate-specific membrane antigen

Identifiers

PMID31481575
PMCPMC8801960
OpenAlexW2971373538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.