Evidence map›Paper›PMID 31481499›Full record

ArticleCancer research2019

Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host-Virus Interactions.

Srishti Chakravorty, Bingyu Yan, Chong Wang, Luopin Wang, Joseph Taylor Quaid, Chin Fang Lin, Scott D Briggs, Joydeb Majumder, D Alejandro Canaria, Daniel Chauss and 5 more

Open access · greenAbstract readComment
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 58 citations in OpenAlex.

  1. Epstein-Barr Virus in Brain Cancer-Friend or Foe?International journal of molecular sciences · 2026
    Article
  2. Article
  3. Epstein-Barr Virus-Associated T/NK-Cell Neoplasms.Journal of medical virology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The cancer microbiome.Advances in clinical chemistry · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Srishti ChakravortyDepartment of Biochemistry, Purdue University, West Lafayette, Indiana.
Bingyu YanDepartment of Biochemistry, Purdue University, West Lafayette, Indiana.ORCID 0000-0003-4429-8200
Chong WangDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Luopin WangDepartment of Computer Science, Purdue University, West Lafayette, Indiana.
Joseph Taylor QuaidDepartment of Biochemistry, Purdue University, West Lafayette, Indiana.ORCID 0000-0002-9198-2665
Chin Fang LinDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana.
Scott D BriggsDepartment of Biochemistry, Purdue University, West Lafayette, Indiana.
Joydeb MajumderDepartment of Chemistry, Purdue University, West Lafayette, Indiana.
D Alejandro CanariaDepartment of Biological Science, Purdue University, West Lafayette, Indiana.
Daniel ChaussImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.ORCID 0000-0002-8343-0860
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, Indiana.ORCID 0000-0003-0942-7898
Matthew R OlsonDepartment of Biological Science, Purdue University, West Lafayette, Indiana.
Bo ZhaoDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Behdad AfzaliImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.ORCID 0000-0003-2968-1156
Majid KazemianDepartment of Biochemistry, Purdue University, West Lafayette, Indiana. kazemian@purdue.edu.
Purdue University West Lafayette · USBrigham and Women's Hospital · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Unravelling immunoregulatory circuits of tissue inflammationZIADK075149 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI AFZALI, BEHDAD · 2019 to 2025
$19.3M
SET Domain Epigenetic Factors Govern Antifungal Drug Efficacy and Fungal PathogenesisR01AI136995 · NIAID · PURDUE UNIVERSITY · PI BRIGGS, SCOTT D · 2018 to 2022
$1.9M
Expression, regulation, and role of enhancer RNAs in T helper cellsK22HL125593 · NHLBI · PURDUE UNIVERSITY · PI KAZEMIAN, MAJID · 2017 to 2019
$747k
NHLBI NIH HHS K22 HL125593NIAID NIH HHS R01 AI136995Wellcome Trust
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a complex oncogenic symbiont. The molecular mechanisms governing EBV carcinogenesis remain elusive and the functional interactions between virus and host cells are incompletely defined. Here we present a comprehensive map of the host cell-pathogen interactome in EBV-associated cancers. We systematically analyzed RNA sequencing from >1,000 patients with 15 different cancer types, comparing virus and host factors of EBV

Indexed as

Epstein-Barr Virus InfectionsNeoplasmsGene Expression ProfilingHerpesvirus 4, HumanHumansSequence Analysis, RNA

Identifiers

PMID31481499
PMCPMC6891172
OpenAlexW2972250108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.