Evidence map›Paper›PMID 31481498›Full record

ArticleCancer research2019

Hanna Foster, E Josue Ruiz, Christopher Moore, Gordon W H Stamp, Emma L Nye, Ningning Li, Yihang Pan, Yulong He, Julian Downward, Axel Behrens

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hanna FosterAdult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom.
E Josue RuizAdult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom.
Christopher MooreOncogene Biology Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-4653-1427
Gordon W H StampExperimental Histopathology Laboratory, The Francis Crick Institute, London, United Kingdom.
Emma L NyeExperimental Histopathology Laboratory, The Francis Crick Institute, London, United Kingdom.
Ningning LiAdult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom.
Yihang PanTomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Yulong HeTomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Julian DownwardOncogene Biology Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-2331-4729
Axel BehrensAdult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom. axel.behrens@crick.ac.uk.
The Francis Crick Institute · GBSun Yat-sen University · CNKing's College London · GB

Funding

Cancer Research UK FC001039European Research Council 281661Wellcome Trust FC001039
6 · The paper itself

Abstract

Tumor cells proliferate rapidly and thus are frequently subjected to replication stress and the risk of incomplete duplication of the genome. Fragile sites are replicated late, making them more vulnerable to damage when DNA replication fails to complete. Therefore, genomic alterations at fragile sites are commonly observed in tumors. FRA16D is one of the most common fragile sites in lung cancer, however, the nature of the tumor suppressor genes affected by FRA16D alterations has been controversial. Here, we show that the

Indexed as

Genes, Tumor SuppressorAdenocarcinomaAnimalsCells, CulturedChromosome Fragile SitesChromosomes, Human, Pair 16DNA DamageGene Expression Regulation, NeoplasticGenotypeHumansKaplan-Meier EstimateLung NeoplasmsMiceNeoplasm GradingTranscription FactorsTumor BurdenATMIN protein, humanATMIN protein, mouseTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID31481498
PMCPMC6797498
OpenAlexW2971999903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.