Evidence map›Paper›PMID 31481470›Full record

ArticleThe Journal of biological chemistry2019

Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells.

Qinghong Dan, Yixuan Shi, Razieh Rabani, Shruthi Venugopal, Jenny Xiao, Shaista Anwer, Mei Ding, Pam Speight, Wanling Pan, R Todd Alexander and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Claudin-2 Mediates the Proximal Tubular Epithelial Cell-Fibroblast Crosstalk via Paracrine CTGF.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  7. The role of claudins in homeostasis.Nature reviews. Nephrology · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. MRTF: Basic Biology and Role in Kidney Disease.International journal of molecular sciences · 2021
    Review
  17. Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation.Journal of experimental & clinical cancer research : CR · 2021
    Article
  18. Article
  19. Article
  20. Claudin-2: Roles beyond Permeability Functions.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Qinghong DanKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Yixuan ShiKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Razieh RabaniKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Shruthi VenugopalKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Jenny XiaoKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Shaista AnwerKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Mei DingKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Pam SpeightKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Wanling PanDepartments of Pediatrics and Physiology, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
R Todd AlexanderDepartments of Pediatrics and Physiology, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.ORCID 0000-0001-7396-7894
András KapusKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Katalin SzásziKeenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada katalin.szaszi@unityhealth.to.ORCID 0000-0002-2490-8422
St. Michael's Hospital · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na

Indexed as

AnimalsClaudinsFemaleHumansKidney TubulesLLC-PK1 CellsMaleMiceMice, Inbred C57BLPhenotyperhoA GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsSwineTrans-ActivatorsTumor Necrosis Factor-alphaUreteral ObstructionArhgef2 protein, mouseClaudinsCldn2 protein, mouseMrtfa protein, mouserhoA GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsTrans-ActivatorsTumor Necrosis Factor-alphaclaudinepithelial cellepithelial-mesenchymal transition (EMT)guanine nucleotide exchange factor (GEF)p27KIP1pro-fibrotic epithelial phenotypeRas homolog gene family, member A (RhoA)renal tubulessmall GTPasetight junction

Identifiers

PMID31481470
PMCPMC6802501
OpenAlexW2972040147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.