Evidence map›Paper›PMID 31481438›Full record

ArticleAntimicrobial agents and chemotherapy2019

Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.

Letícia Sayuri Murase, João Vítor Perez de Souza, Jean Eduardo Meneguello, Flavio Augusto Vicente Seixas, Laíse Adriane Hegeto, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi Ferracioli, Rosilene Fressatti Cardoso

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Letícia Sayuri Murase *Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil le.murase@gmail.com.
João Vítor Perez de Souza *Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Jean Eduardo MeneguelloDepartment of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Flavio Augusto Vicente SeixasDepartment of Technology, State University of Maringa, Umuarama, Paraná, Brazil.
Laíse Adriane HegetoDepartment of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Regiane Bertin de Lima ScodroDepartment of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Vera Lucia Dias SiqueiraDepartment of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Katiany Rizzieri Caleffi Ferracioli *Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Rosilene Fressatti Cardoso *Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Universidade Estadual de Maringá · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in

Indexed as

AlkaloidsAntineoplastic AgentsBenzodioxolesBinding SitesDNA-Directed RNA PolymerasesDrug SynergismDrug Therapy, CombinationMolecular Docking SimulationMycobacterium tuberculosisPiperidinesPolyunsaturated AlkamidesReverse Transcriptase Polymerase Chain ReactionRifampinAlkaloidsAntineoplastic AgentsBenzodioxolesDNA-Directed RNA PolymerasesPiperidinespiperinePolyunsaturated AlkamidesRifampindockingefflux pumpspiperinerifampinRNA polymerasetuberculosis

Identifiers

PMID31481438
PMCPMC6811433
OpenAlexW2970157211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.