Evidence map›Paper›PMID 31481392›Full record

ArticleThe British journal of ophthalmology2019

Universal artificial intelligence platform for collaborative management of cataracts.

Xiaohang Wu, Yelin Huang, Zhenzhen Liu, Weiyi Lai, Erping Long, Kai Zhang, Jiewei Jiang, Duoru Lin, Kexin Chen, Tongyong Yu and 27 more

Abstract readValidation Study
In one paragraph

Article in The British journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Xiaohang Wu *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yelin Huang *Beijing Tulip Partners Technology Co., Ltd, Beijing, China.
Zhenzhen LiuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Weiyi LaiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Erping LongState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Kai ZhangSchool of Computer Science and Technology, Xidian University, Xi'an, China.
Jiewei JiangSchool of Computer Science and Technology, Xidian University, Xi'an, China.
Duoru LinState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Kexin ChenZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Tongyong YuZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Dongxuan WuZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Cong LiZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yanyi ChenZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Minjie ZouZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Chuan ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yi ZhuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Chong GuoState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiayin ZhangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Ruixin WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yahan YangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yifan XiangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Lijian ChenBeijing Tulip Partners Technology Co., Ltd, Beijing, China.
Congxin LiuBeijing Tulip Partners Technology Co., Ltd, Beijing, China.
Jianhao XiongBeijing Tulip Partners Technology Co., Ltd, Beijing, China.
Zongyuan GeDepartment of Electrical and Computer Systems Engineering, Faculty of Engineering, Monash University, Melbourne, Victoria, Australia.
Dingding WangHuizhou Municipal Central Hospital, Huizhou, China.
Guihua XuHuizhou Municipal Central Hospital, Huizhou, China.
Shaolin DuTung Wah Hospital, Sun Yat-sen University, Dongguan, China.
Chi XiaoDongguan Guangming Ophthalmic Hospital, Dongguan, China.
Jianghao WuDongguan Guangming Ophthalmic Hospital, Dongguan, China.
Ke ZhuKaifeng Eye Hospital, Kaifeng, China.
Danyao NieShenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Shenzhen University School of Medicine, Shenzhen, China.
Fan XuDepartment of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Jian LvDepartment of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Weirong ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yizhi LiuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-2067-2707

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo establish and validate a universal artificial intelligence (AI) platform for collaborative management of cataracts involving multilevel clinical scenarios and explored an AI-based medical referral pattern to improve collaborative efficiency and resource coverage.

methodsThe training and validation datasets were derived from the Chinese Medical Alliance for Artificial Intelligence, covering multilevel healthcare facilities and capture modes. The datasets were labelled using a three-step strategy: (1) capture mode recognition; (2) cataract diagnosis as a normal lens, cataract or a postoperative eye and (3) detection of referable cataracts with respect to aetiology and severity. Moreover, we integrated the cataract AI agent with a real-world multilevel referral pattern involving self-monitoring at home, primary healthcare and specialised hospital services.

resultsThe universal AI platform and multilevel collaborative pattern showed robust diagnostic performance in three-step tasks: (1) capture mode recognition (area under the curve (AUC) 99.28%-99.71%), (2) cataract diagnosis (normal lens, cataract or postoperative eye with AUCs of 99.82%, 99.96% and 99.93% for mydriatic-slit lamp mode and AUCs >99% for other capture modes) and (3) detection of referable cataracts (AUCs >91% in all tests). In the real-world tertiary referral pattern, the agent suggested 30.3% of people be 'referred', substantially increasing the ophthalmologist-to-population service ratio by 10.2-fold compared with the traditional pattern.

conclusionsThe universal AI platform and multilevel collaborative pattern showed robust diagnostic performance and effective service for cataracts. The context of our AI-based medical referral pattern will be extended to other common disease conditions and resource-intensive situations.

Indexed as

Artificial IntelligenceIntersectoral CollaborationAdolescentAdultAgedAged, 80 and overArea Under CurveCataractCataract ExtractionFemaleHumansMaleMass ScreeningMiddle AgedROC CurveSlit Lamp MicroscopyDiagnostic tests/InvestigationImagingLens and zonulesPublic health

Identifiers

PMID31481392
PMCPMC6855787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.