Evidence map›Paper›PMID 31481127›Full record

ArticleActa neuropathologica communications2019

Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination.

Fiona Tea, Joseph A Lopez, Sudarshini Ramanathan, Vera Merheb, Fiona X Z Lee, Alicia Zou, Deepti Pilli, Ellis Patrick, Anneke van der Walt, Mastura Monif and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 104 citations in OpenAlex.

  1. Beyond Positivity: Understanding and Interpreting MOG-IgG Testing in MOGAD.Journal of clinical neurology (Seoul, Korea) · 2026
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  16. The clinical relevance of MOG antibody testing in cerebrospinal fluid.Annals of clinical and translational neurology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 2 countries.

Fiona TeaBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Joseph A LopezBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Sudarshini RamanathanBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Vera MerhebBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Fiona X Z LeeBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Alicia ZouBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Deepti PilliBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Ellis PatrickDiscipline of Applied Medical Science, The University of Sydney, Sydney, Australia.
Anneke van der WaltDepartment of Neurosciences, Central Clinical School, Monash University, Melbourne, Australia.
Mastura MonifDepartment of Neurosciences, Central Clinical School, Monash University, Melbourne, Australia.
Esther M TantsisBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Eppie M YiuDepartment of Neurology, Royal Children's Hospital and Neurosciences Research, Murdoch Children's Research Institute, Melbourne, Australia.
Steve VucicDepartment of Neurology, Westmead Hospital, Sydney, Australia.
Andrew P D HendersonDepartment of Neurology, Westmead Hospital, Sydney, Australia.
Anthony FokDepartment of Neurology, Monash Health, Melbourne, Australia.
Clare L FraserSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Jeanette Lechner-ScottHunter Medical Research Institute, Newcastle, Australia.
Stephen W ReddelBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Simon BroadleyDepartment of Neurology, School of Medicine, Gold Coast University Hospital, Griffith University, Gold Coast, Australia.
Michael H BarnettBrain and Mind Centre, The University of Sydney, Sydney, Australia.
David A BrownNew South Wales Health Pathology, Institute of Clinical Pathology and Medical Research, and Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
Jan D LunemannDepartment of Neurology, University of Münster, Münster, Germany.
Russell C DaleBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia.
Fabienne BrilotBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW, 2145, Australia. fabienne.brilot@sydney.edu.au.ORCID 0000-0002-7025-2276
Australasian and New Zealand MOG Study Group
The University of Sydney · AUChildren's Hospital at Westmead · AUGriffith University · AUWestmead Hospital · AUMonash University · AURoyal Children's Hospital · AU

Funding

Multiple Sclerosis Research Australia G173565National Health and Medical Research Council APP1142008Sydney Research Excellence Initiative 2020 G201115
6 · The paper itself

Abstract

Over recent years, human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have been associated with monophasic and relapsing central nervous system demyelination involving the optic nerves, spinal cord, and brain. While the clinical relevance of MOG Ab detection is becoming increasingly clear as therapeutic and prognostic differences from multiple sclerosis are acknowledged, an in-depth characterization of human MOG Ab is required to answer key challenges in patient diagnosis, treatment, and prognosis. Herein, we investigated the epitope, binding sensitivity, and affinity of MOG Ab in a cohort of 139 and 148 MOG antibody-seropositive children and adults (n = 287 patients at baseline, 130 longitudinal samples, and 22 cerebrospinal fluid samples). MOG extracellular domain was also immobilized to determine the affinity of MOG Ab. MOG Ab response was of immunoglobulin G1 isotype, and was of peripheral rather than intrathecal origin. High affinity MOG Ab were detected in 15% paediatric and 18% adult sera. More than 75% of paediatric and adult MOG Ab targeted a dominant extracellular antigenic region around Proline42. MOG Ab titers fluctuated over the progression of disease, but affinity and reactivity to Proline42 remained stable. Adults with a relapsing course intrinsically presented with a reduced immunoreactivity to Proline42 and had a more diverse MOG Ab response, a feature that may be harnessed for predicting relapse. Higher titers of MOG Ab were observed in more severe phenotypes and during active disease, supporting the pathogenic role of MOG Ab. Loss of MOG Ab seropositivity was observed upon conformational changes to MOG, and this greatly impacted the sensitivity of the detection of relapsing disorders, largely considered as more severe. Careful consideration of the binding characteristics of autoantigens should be taken into account when detecting disease-relevant autoantibodies.

Indexed as

AdolescentAdultAutoantibodiesChildChild, PreschoolDemyelinating DiseasesEpitopesFemaleHumansMaleMiddle AgedMyelin-Oligodendrocyte GlycoproteinOptic NeuritisProtein BindingProtein ConformationYoung AdultAutoantibodiesEpitopesMOG protein, humanMyelin-Oligodendrocyte GlycoproteinAntibodyDiagnosisEpitope, antigen conformationMultiple sclerosisMyelin oligodendrocyte glycoproteinOptic neuritis

Identifiers

PMID31481127
PMCPMC6724269
OpenAlexW2971598630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.