Evidence map›Paper›PMID 31481093›Full record

ArticleItalian journal of pediatrics2019

Intranasal dexmedetomidine and intravenous ketamine for procedural sedation in a child with alpha-mannosidosis: a magic bullet?

Matteo Trevisan, Sara Romano, Egidio Barbi, Irene Bruno, Flora Maria Murru, Giorgio Cozzi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matteo TrevisanDepartment of Medicine, Surgery, and Health Sciences, University of Trieste, Trieste, Italy.
Sara RomanoDepartment of Medicine, Surgery, and Health Sciences, University of Trieste, Trieste, Italy. sara.romano17@gmail.com.ORCID http://orcid.org/0000-0002-1289-6401
Egidio BarbiDepartment of Medicine, Surgery, and Health Sciences, University of Trieste, Trieste, Italy.
Irene BrunoDepartment of Radiology, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Flora Maria MurruDepartment of Pediatrics, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy. Via dell'Istria 65/1, 34131, Trieste, Italy.
Giorgio CozziPediatric Emergency Department, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy. Via dell'Istria 65/1, 34131, Trieste, Italy.
IRCCS Materno Infantile Burlo Garofolo · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProcedural sedation is increasingly needed in pediatrics. Although different drugs or drugs association are available, which is the safest and most efficient has yet to be defined, especially in syndromic children with increased sedation-related risk factors. CASE REPORT: we report the case of a five-year-old child affected by alpha-mannosidosis who required procedural sedation for an MRI scan and a lumbar puncture. We administered intranasal dexmedetomidine (4 μg/kg) 45 min before intravenous cannulation, followed by one bolus of ketamine (1 mg/kg) for each procedure. The patient maintained spontaneous breathing and no desaturation or any complication occurred.

conclusionintranasal dexmedetomidine and intravenous ketamine could be a feasible option for MRI and lumbar puncture in children with alpha-mannosidosis needing sedation.

Indexed as

Administration, Intranasalalpha-MannosidosisAnesthetics, DissociativeChild, PreschoolDexmedetomidineHumansHypnotics and SedativesInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleSpinal PunctureAnesthetics, DissociativeDexmedetomidineHypnotics and SedativesKetamineAlpha-mannosidosisDexmedetomidineKetamineProcedural sedation

Identifiers

PMID31481093
PMCPMC6720406
OpenAlexW2971672785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.