ArticleBMC musculoskeletal disorders2019
Tranexamic acid may benefit patients undergoing total hip/knee arthroplasty because of haemophilia.
Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Perioperative bleeding control in total hip arthroplasty: hemostatic powder vs. tranexamic acid-a prospective randomized controlled trial.Archives of orthopaedic and trauma surgery · 2024Trial
- Real-Time Coagulation Monitoring via Thromboelastography and Platelet Mapping in Total Hip Arthroplasty for a Patient with Factor XI Deficiency: A Case Report.Journal of orthopaedic case reports · 2026Article
- Normal Haemostasis, Inherited Bleeding Disorders and Surgery: What Does the Anaesthesiologist Need to Know?Medicina (Kaunas, Lithuania) · 2025Review
- Clinical outcomes of total hip and knee arthroplasty for end-stage hemophilic arthropathy in patients with hemophilia: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Total Hip Arthroplasty for Avascular Necrosis in a Patient With Hemophilia B.Arthroplasty today · 2024Article
- Morphological Measurement and Clinical Significance of Abnormal Development of Distal Femur with Hemophilia Knee Arthritis: A Consideration on the Renewal of Total Knee Prosthesis.Orthopaedic surgery · 2024Article
- Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty.International orthopaedics · 2024Article
- The effect of triple-dose-intravenous tranexamic acid on blood loss in patients undergoing total hip arthroplasty without affecting blood coagulopathy: A prospective thromboelastographic analysis.Acta orthopaedica et traumatologica turcica · 2023Article
- Primary total knee arthroplasty in hemophilic arthropathy.EFORT open reviews · 2023Review
- Short-term outcome of total knee replacement in a patient with hemophilia: A case report and review of literature.World journal of clinical cases · 2023Article
- Total Hip Arthroplasty in Patients with Hemophilia: What Do We know?The archives of bone and joint surgery · 2023Review
- Hidden blood loss of total knee arthroplasty in hemophilia arthritis: an analysis of influencing factors.BMC musculoskeletal disorders · 2022Article
- The efficacy and safety of intravenous tranexamic acid on blood loss during total ankle replacement: a retrospective study.Scientific reports · 2022Article
- Does systemic lupus erythematosus increase the risk of complications from total hip arthroplasty?BMC musculoskeletal disorders · 2021Article
- Identifying Risk Factors Associated With Postoperative Infection Following Elective Lower-Extremity Total Joint Arthroplasty.The Permanente journal · 2020Review
- Total knee arthroplasty in hemophilia A.Arthroplasty today · 2020Article
- Tranexamic Acid Is Beneficial to Patients Undergoing Open-Wedge High Tibial Osteotomy.BioMed research international · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe lower limb joints, including hip and knee, are the most commonly involved joints in haemophilic arthropathy. With a higher risk of transfusion, total hip and knee arthroplasty (THA and TKA) are still the first choice after failure of conservative treatment. In the present study, we aimed to analyze clinical outcomes and complications rate after total joint arthroplasty of the lower limbs using tranexamic acid (TXA) or not.
methodsThirty-four patients with haemophilia A undergoing 24 TKA and 18 THA were evaluated in this retrospective study (No. 201302009). Based on using TXA or not, they were divided into either TXA (12 knees and 10 hips) or Non-TXA groups (12 knees and 8 hips). Total blood loss, intraoperative blood loss, total amount of FVIII usage, range of motion, inflammatory biomarkers, joint function, pain status, complication rate and patient satisfaction were assessed and compared at a mean follow-up of 68 months.
resultsUsage of TXA can decrease not only the perioperative blood loss (p = 0.001), transfusion rate (p = 0.017) and supplemental amount of FVIII (p < 0.001) but also swelling ratio, surgical joint pain. Moreover, compared with non-TXA group, the patients in TXA group had a lower level of inflammatory biomarkers and better joint function.
conclusionThe hemophiliacs treated with TXA had less perioperative blood loss, hidden blood loss, transfusion rate, a lower ratio of postoperative knee swelling, less postoperative joint pain, lower levels of inflammatory biomarkers and better joint function. Further studies need performing to assess the long-term effects of TXA in these patients.
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