Evidence map›Paper›PMID 31481031›Full record

Observational studyBMC nephrology2019

Non-invasive hemodynamic profiling of patients undergoing hemodialysis - a multicenter observational cohort study.

Keren Doenyas-Barak, Marcia H F G de Abreu, Lucas E Borges, Helcio A Tavares Filho, Feng Yunlin, Zou Yurong, Nathan W Levin, Allen M Kaufman, Shay Efrati, David Pereg and 3 more

Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Reliability and benefit of estimated continuous cardiac output measurement using shunt-side SpOTherapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025
    Observational
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. The renal replacement therapy landscape in 2030: reducing the global cardiovascular burden in dialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Keren Doenyas-BarakNephrology Department Shamir Medical Center (Assaf-Harofeh campus), Zeriffin, Israel.
Marcia H F G de AbreuBiocor Hospital de Doenças Cardiovasculares, Belo Horizonte, Brazil.
Lucas E BorgesBiocor Hospital de Doenças Cardiovasculares, Belo Horizonte, Brazil.
Helcio A Tavares FilhoBiocor Hospital de Doenças Cardiovasculares, Belo Horizonte, Brazil.
Feng YunlinRenal Division, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.
Zou YurongRenal Division, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.
Nathan W LevinMt. Sinai School of Medicine, New York, NY, USA.
Allen M KaufmanDialyze Direct, Brooklyn, NY, USA.
Shay EfratiNephrology Department Shamir Medical Center (Assaf-Harofeh campus), Zeriffin, Israel.
David PeregSackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
Ilya LitovchikSackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
Shmuel FuchsSackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
Sa'ar MinhaSackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel. minha@asaf.health.gov.il.ORCID 0000-0002-1360-5733
Tel Aviv University · ILBiocor Institute · BRSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNMount Sinai Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntradialytic blood pressure (BP) measurement is currently the main parameter used for monitoring hemodynamics during hemodialysis (HD). Since BP is dependent on cardiac output and total peripheral resistance, knowledge of these parameters throughout the HD treatment would potentially be valuable.

methodsThe use of a novel non-invasive monitoring system for profiling hemodynamic response patterns during HD was explored: a whole-body bio-impedance system was used to assess cardiac index (CI), total peripheral resistance index (TPRI), cardiac power index (CPI) among other parameters in chronic HD patients from 4 medical centers. Measurements were made pre, during and post dialysis. Patients were grouped into 5 hemodynamic profiles based on their main hemodynamic response during dialysis i.e. high TPRI; high CPI; low CPI; low TPRI and those with normal hemodynamics. Comparisons were made between the groups for baseline characteristics and 1-year mortality.

resultsIn 144 patients with mean age of 67.3 ± 12.1 years pre-dialysis hemodynamic measurements were within normal limits in 35.4% but only 6.9% overall remained hemodynamically stable during dialysis. Intradialytic BP decreased in 65 (45.1%) in whom, low CPI (47 (72.3%)) and low TPRI (18 (27.7%) were recorded. At 1-year follow-up, mortality rates were highest in patients with low CPI (23.4%) and low TPRI (22.2%).

conclusionsNon-invasive assessment of patients' response to HD provides relevant hemodynamic information that exceeds that provided by currently used BP measurements. Use of these online analyses could potentially improve the safety and performance standards of dialysis by guiding appropriate interventions, particularly in responding to hypertension and hypotension.

Indexed as

Proof of Concept StudyAgedCardiac OutputCohort StudiesFemaleFollow-Up StudiesHemodynamicsHumansMaleMiddle AgedProspective StudiesRenal DialysisRenal Insufficiency, ChronicVascular ResistanceHemodynamicsIntradialytic hypotensionNon-invasive monitoring

Identifiers

PMID31481031
PMCPMC6724365
OpenAlexW2971882518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.