ArticlePharmaceutics2019
Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties.
Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of resveratrol on skin wound healing, scarring, and aging.International wound journal · 2022Pooled it
- In Vitro Release of Curcumin and Resveratrol from Polymeric Systems: Films and Hydrogel.Gels (Basel, Switzerland) · 2026Article
- Engineering Functional PVA: A Comprehensive Review of Chemical Modifications and Prospective Developments.ACS polymers Au · 2026Review
- Influence of Polymers Diversity on the Dissolution Kinetics of EncapsulatedGels (Basel, Switzerland) · 2025Article
- The Application of Hydrogels in the Treatment of Intrauterine Adhesions.Current pharmaceutical design · 2025Review
- Potential Unlocking of Biological Activity of Caffeic Acid by Incorporation into Hydrophilic Gels.Gels (Basel, Switzerland) · 2024Article
- Single-Walled (Magnetic) Carbon Nanotubes in a Pectin Matrix in the Design of an Allantoin Delivery System.ACS omega · 2024Article
- Date Palm Extract (Plants (Basel, Switzerland) · 2023Article
- Immobilization of Bacteriophages in Ex Tempore Hydrogel for the Treatment of Burn Wound Infection.Gels (Basel, Switzerland) · 2023Article
- Determination of the Bioactive Compounds fromMolecules (Basel, Switzerland) · 2023Article
- Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds.Pharmaceutics · 2023Review
- Emerging Effects of Resveratrol Derivatives in Cells Involved in Oral Wound Healing: A Preliminary Study.International journal of molecular sciences · 2023Article
- Sugarcane Bagasse-Derived Cellulose Nanocrystal/Polyvinyl Alcohol/Gum Tragacanth Composite Film Incorporated with Betel Leaf Extract as a Versatile Biomaterial for Wound Dressing.International journal of biomaterials · 2023Article
- Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels.Frontiers in bioengineering and biotechnology · 2023Review
- Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review.Molecules (Basel, Switzerland) · 2022Review
- Article
- Degradation-Dependent Protein Release from Enzyme Sensitive Injectable Glycol Chitosan Hydrogel.Tissue engineering. Part A · 2021Article
- Application of Bioactive Hydrogels for Functional Treatment of Intrauterine Adhesion.Frontiers in bioengineering and biotechnology · 2021Review
- Viability of Bacteriophages in the Complex Hydrogel Wound DressingsSovremennye tekhnologii v meditsine · 2021Article
- Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths.Pharmaceutics · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
This research proposes the rational modeling, synthesis and evaluation of film dressing hydrogels based on polyvinyl alcohol crosslinked with 20 different kinds of dicarboxylic acids. These formulations would allow the sustained release of simultaneous bioactive compounds including allantoin, resveratrol, dexpanthenol and caffeic acid as a multi-target therapy in wound healing. Interaction energy calculations and molecular dynamics simulation studies allowed evaluating the intermolecular affinity of the above bioactive compounds by hydrogels crosslinked with the different dicarboxylic acids. According to the computational results, the hydrogels crosslinked with succinic, aspartic, maleic and malic acids were selected as the best candidates to be synthesized and evaluated experimentally. These four crosslinked hydrogels were prepared and characterized by FTIR, mechanical properties, SEM and equilibrium swelling ratio. The sustained release of the bioactive compounds from the film dressing was investigated in vitro and in vivo. The in vitro results indicate a good release profile for all four analyzed bioactive compounds. More importantly, in vivo experiments suggest that prepared formulations could considerably accelerate the healing rate of artificial wounds in rats. The histological studies show that these formulations help to successfully reconstruct and thicken epidermis during 14 days of wound healing. Moreover, the four film dressings developed and exhibited excellent biocompatibility. In conclusion, the novel film dressings based on hydrogels rationally designed with combinatorial and sustained release therapy could have significant promise as dressing materials for skin wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.