ArticleJournal of clinical medicine2019
Pregabalin Failed to Prevent Dry Eye Symptoms after Laser-Assisted in Situ Keratomileusis (LASIK) in a Randomized Pilot Study.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Efficacy of gabapentin and pregabalin for treatment of post refractive surgery pain: a systematic review and meta-analysis.International ophthalmology · 2024Pooled it
- Pain sensitivity and autonomic nervous system parameters as predictors of dry eye symptoms after LASIK.The ocular surface · 2021Trial
- Differences in pre-surgical baseline tear proteome are associated with persistent post-refractive surgery pain.The ocular surface · 2025Article
- Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study.The ocular surface · 2024Article
- Ocular Pain after Refractive Surgery: Interim Analysis of Frequency and Risk Factors.Ophthalmology · 2023Article
- Post-LASIK dry eye disease: A comprehensive review of management and current treatment options.Frontiers in medicine · 2023Review
- Opioids and Ocular Surface Pathology: A Literature Review of New Treatments Horizons.Journal of clinical medicine · 2022Review
- Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study.Journal of clinical medicine · 2021Article
- Treatment Response to Gabapentin in Neuropathic Ocular Pain Associated with Dry Eye.Journal of clinical medicine · 2020Article
- Autoimmune Dry Eye without Significant Ocular Surface Co-Morbidities and Mental Health.Vision (Basel, Switzerland) · 2020Review
- Comparison of clinical characteristics of post-refractive surgery-related and post-herpetic neuropathic corneal pain.The ocular surface · 2020Article
- Why Internists Should Care About Dry Eye Disease.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePerioperative pregabalin administration has been found to reduce the risk of persistent pain after a variety of surgical procedures. However, this approach has not been tested in relation to eye surgery. As such, the purpose of this study was to evaluate whether perioperative pregabalin can reduce the presence of dry eye (DE) symptoms, including eye pain, six months after laser-assisted in situ keratomileusis (LASIK).
methodsProspective, masked, randomized single-center pilot study. Patients were treated with either pregabalin (oral solution of pregabalin 150 mg twice daily, first dose prior to surgery, continued for a total of 28 doses over 14 days) or placebo solution. The primary outcome was dry eye symptoms as measured by the Dry Eye Questionnaire 5 (DEQ-5). Secondary outcome measures included pain-related eye symptoms.
resultsIn total, 43 individuals were enrolled in the study and randomized to pregabalin (
conclusionsPerioperative pregabalin did not reduce the frequency or severity of DE symptoms at a six month follow-up after LASIK in this small pilot study.
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