Evidence map›Paper›PMID 31480575›Full record

ArticleBiomolecules2019

Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice.

Bihui Liu, Jing Zhang, Peng Sun, Ruokun Yi, Xiaoyan Han, Xin Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 91 citations in OpenAlex.

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  13. Frontiers in microbiology · 2024
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  17. Total Flavonoids fromFoods (Basel, Switzerland) · 2022
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bihui LiuChongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.
Jing ZhangEnvironment and Quality Inspection College, Chongqing Chemical Industry Vocational College, Chongqing 401228, China.
Peng SunChongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.
Ruokun YiChongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.
Xiaoyan HanChongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.
Xin ZhaoChongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China. zhaoxin@cque.edu.cn.ORCID 0000-0001-9798-7865
Chongqing University of Education · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high-fat diet-induced C57BL/6N mouse model of non-alcoholic fatty liver disease (NAFLD) was established. The effect and mechanism of Raw Bowl Tea polyphenols (RBTP) on preventing NAFLD via regulating intestinal function were observed. The serum, liver, epididymis, small intestine tissues, and feces of mice were examined by biochemical and molecular biological methods, and the composition of RBTP was analyzed by HPLC assay. The results showed that RBTP could effectively reduce the body weight, liver weight, and liver index of NAFLD mice. The serum effects of RBTP were: (1) decreases in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), D-lactate (D-LA), diamine oxidase (DAO), lipopolysaccharide (LPS), and an increase of high density lipoprotein cholesterol (HDL-C) levels; (2) a decrease of inflammatory cytokines such as interleukin 1 beta (IL-1β), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α), and interferon gamma (INF-γ); (3) a decrease the reactive oxygen species (ROS) level in liver tissue; and (4) alleviation of pathological injuries of liver, epididymis, and small intestinal tissues caused by NAFLD and protection of body tissues. qPCR and Western blot results showed that RBTP could up-regulate the mRNA and protein expressions of LPL, PPAR-α, CYP7A1, and CPT1, and down-regulate PPAR-γ and C/EBP-α in the liver of NAFLD mice. In addition, RBTP up-regulated the expression of occludin and ZO-1, and down-regulated the expression of CD36 and TNF-α in the small intestines of NAFLD mice. Studies on mice feces showed that RBTP reduced the level of

Indexed as

Alanine TransaminaseAnimalsBacteroidesCatechinCytokinesDisease Models, AnimalFecesFemaleIntestinesLiverMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseOccludinPolyphenolsAlanine TransaminaseCatechinCytokinesepicatechin gallateepigallocatechin gallategallocatechin gallategallocatecholOccludinPolyphenolsTeaintestinal functionmicenonalcoholic fatty liver diseasepolyphenolsraw Bowl tea

Identifiers

PMID31480575
PMCPMC6770140
OpenAlexW2971214020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.