Evidence map›Paper›PMID 31480518›Full record

ArticleInternational journal of molecular sciences2019

Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair.

Katharina Krüger, Sebastian Schmid, Friedrich Paulsen, Anita Ignatius, Patricia Klinger, Thilo Hotfiel, Bernd Swoboda, Kolja Gelse

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Katharina KrügerDepartment of Orthopaedic Trauma Surgery, University Hospital Erlangen, 91054 Erlangen, Germany.
Sebastian SchmidDepartment of Orthopaedic Trauma Surgery, University Hospital Erlangen, 91054 Erlangen, Germany.
Friedrich PaulsenInstitute of Functional and Clinical Anatomy, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.
Anita IgnatiusInstitute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany.ORCID 0000-0002-4782-1979
Patricia KlingerDepartment of Orthopaedic Trauma Surgery, University Hospital Erlangen, 91054 Erlangen, Germany.
Thilo HotfielDivision of Orthopaedic Rheumatology, Department of Orthopaedics, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.
Bernd SwobodaDivision of Orthopaedic Rheumatology, Department of Orthopaedics, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.
Kolja GelseDepartment of Orthopaedic Trauma Surgery, University Hospital Erlangen, 91054 Erlangen, Germany. kolja.gelse@web.de.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversitätsklinikum Erlangen · DEUniversität Ulm · DE

Funding

Deutsche Forschungsgemeinschaft PA738/9-2Friedrich-Alexander-Universität Erlangen-Nürnberg EFI-MoJo-3DMedizinische Fakultät, Friedrich-Alexander-Universität Erlangen-Nürnberg Marohn Foundation FWN/Zo - Gel/2014
6 · The paper itself

Abstract

The aim of the study was to explore the possible role of Trefoil Factor Family peptide 3 (TFF3) for skeletal repair. The expression of TFF3 was analyzed in human joint tissues as well as in a murine bone fracture model. Serum levels of TFF3 following a defined skeletal trauma in humans were determined by ELISA. The mRNA expression of TFF3 was analyzed under normoxia and hypoxia. Expression analysis after stimulation of human mesenchymal progenitor cells (MPCs) with TFF3 was performed by RT

Indexed as

Cell MovementActin CytoskeletonAgedAged, 80 and overAnimalsBone and BonesFemaleFracture HealingGene Expression RegulationHumansHypoxiaMiceMice, Inbred C57BLMiddle Agedrho-Associated KinasesTrefoil Factor-3rho-Associated KinasesROCK1 protein, humanTrefoil Factor-3cell migrationchemotaxisfracture healingmesenchymal progenitor cellsTFF3

Identifiers

PMID31480518
PMCPMC6747154
OpenAlexW2971303622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.