Evidence map›Paper›PMID 31480444›Full record

ArticleInternational journal of molecular sciences2019

Mismatch Recognition by

Yan Li, Zane Lombardo, Meera Joshi, Manju M Hingorani, Ishita Mukerji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Physical Chemistry and Chemical Physics (PCCP) Section of theInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan LiMolecular Biology and Biochemistry Department, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA.
Zane LombardoMolecular Biology and Biochemistry Department, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA.
Meera JoshiMolecular Biology and Biochemistry Department, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA.
Manju M HingoraniMolecular Biology and Biochemistry Department, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA.
Ishita MukerjiMolecular Biology and Biochemistry Department, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA. imukerji@wesleyan.edu.

Funding

Investigation of defective allosteric signaling as a basis for DNA mismatch repair malfunction in Lynch cancer syndromeR15GM114743 · NIGMS · WESLEYAN UNIVERSITY · PI HINGORANI, MANJU M · 2015 to 2015
$409k
National Science Foundation MCB-0843656NIH HHS R15GM114743
6 · The paper itself

Abstract

The mismatch repair (MMR) pathway maintains genome integrity by correcting errors such as mismatched base pairs formed during DNA replication. In MMR, Msh2-Msh6, a heterodimeric protein, targets single base mismatches and small insertion/deletion loops for repair. By incorporating the fluorescent nucleoside base analog 6-methylisoxanthopterin (6-MI) at or adjacent to a mismatch site to probe the structural and dynamic elements of the mismatch, we address how Msh2-Msh6 recognizes these mismatches for repair within the context of matched DNA. Fluorescence quantum yield and rotational correlation time measurements indicate that local base dynamics linearly correlate with

Indexed as

Base Pair MismatchDNA-Binding ProteinsDNA, FungalModels, MolecularMutS Homolog 2 ProteinProtein BindingProtein ConformationProtein MultimerizationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsDNA, FungalMSH2 protein, S cerevisiaeMSH6 protein, S cerevisiaeMutS Homolog 2 ProteinSaccharomyces cerevisiae Proteins6-methylisoxanthopterin (6-MI)base dynamicsDNA repairfluorescenceFörster resonance energy transfer (FRET)induced fitmismatch repair (MMR)Msh2–Msh6MutSαprotein-DNA interactions

Identifiers

PMID31480444
PMCPMC6747400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.