ArticleAging2019
Discovering markers of healthy aging: a prospective study in a Danish male birth cohort.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- A technical review of canonical correlation analysis for neuroscience applications.Human brain mapping · 2020Pooled it
- The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation.Alzheimer's research & therapy · 2025Article
- On the validity of fMRI mega-analyses using data processed with different pipelines.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Effects of Brain Maintenance and Cognitive Reserve on Age-Related Decline in Three Cognitive Abilities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Power and distribution of evoked gamma oscillations in brain aging and cognitive performance.GeroScience · 2023Article
- Combining reinforcement learning and virtual reality in mild neurocognitive impairment: a new usability assessment on patients and caregivers.Frontiers in aging neuroscience · 2023Article
- Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men.GeroScience · 2022Article
- Confound modelling in UK Biobank brain imaging.NeuroImage · 2021Article
- Discovering correlates of age-related decline in a healthy late-midlife male birth cohort.Aging · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recruited from the 1953 Danish Male Birth Cohort (N=193). Applying an extreme group design, members were selected in 2 groups based on cognitive change between IQ at age ~20y (IQ-20) and age ~57y (IQ-57). Subjects showing the highest (n=95) and lowest (n=98) change were selected (at age ~57) for assessments on multiple IDPs and non-IDPs. We investigated the relationship between 453 IDPs and 70 non-IDPs through pairwise correlation and multivariate canonical correlation analysis (CCA) models. Significant pairwise associations included positive associations between IQ-20 and gray-matter volume of the temporal pole. CCA identified a richer pattern - a single "positive-negative" mode of population co-variation coupling individual cross-subject variations in IDPs to an extensive range of non-IDP measures (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.