Observational studyThe spine journal : official journal of the North American Spine Society2020
Comparison of brain structure between pain-susceptible and asymptomatic individuals following experimental induction of low back pain.
Observational study in The spine journal : official journal of the North American Spine Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Electroacupuncture alleviates pain after total knee arthroplasty through regulating neuroplasticity: A resting-state functional magnetic resonance imaging study.Brain and behavior · 2023Trial
- Alteration in functional connectivity of SC_thalamus with primary trigeminal neuralgia.BMC neurology · 2025Article
- Delayed Recovery After Exercise-Induced Pain in People with Chronic Widespread Muscle Pain Related to Cortical Connectivity.Brain sciences · 2024Article
- Delayed-Onset Muscle Soreness Alters Mechanical Sensitivity, but Not Thermal Sensitivity or Pain Modulatory Function.Journal of pain research · 2024Article
- Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake.Scientific reports · 2023Article
- Alterations in regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in patients with new daily persistent headache: a resting-state functional magnetic resonance imaging study.The journal of headache and pain · 2023Article
- A nomogram based on radiological features of MRI for predicting the risk of severe pain in patients with osteoarthritis of the knee.Frontiers in surgery · 2023Article
- Dynamic local metrics changes in patients with toothache: A resting-state functional magnetic resonance imaging study.Frontiers in neurology · 2022Article
- Alterations of the White Matter in Patients With Knee Osteoarthritis: A Diffusion Tensor Imaging Study With Tract-Based Spatial Statistics.Frontiers in neurology · 2022Article
- Associations of Regional and Network Functional Connectivity With Exercise-Induced Low Back Pain.The journal of pain · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
background contextPeripheral differences often do not adequately account for variation in reports of pain intensity in people with musculoskeletal pain. PURPOSE: Here we sought to determine the extent to which structural differences in the brain (grey matter density) of pain free individuals might relate to subsequent pain (or lack thereof) after standardized peripheral muscle injury (ie, micro trauma from high intensity exercise). STUDY
designThis was an observational laboratory-based study that was a secondary analysis from a larger trial.
methodsParticipants completed baseline testing (functional MRI and quantitative pain testing) followed by high intensity trunk exercise to induce delayed onset muscle soreness in the erector spinae. Forty-eight hours later, back pain intensity ratings were collected and all participants were re-imaged. Grey matter density was determined using voxel-based morphometry. The "asymptomatic" group (no reports of any pain within 48 hours after induction) to a 'pain' group (rating of pain at rest and movement pf>20 on a 101-point numeric rating scale).
resultsOur results revealed several large clusters where, compared to participants with pain, asymptomatic participants had significant greater grey matter density. These brain regions included left medial frontal gyrus, left middle occipital gyrus, left middle temporal gyrus, left inferior frontal gyrus, and right superior frontal gyrus.
conclusionsLower grey matter density in brain regions previously linked to discriminative, emotional, and cognitive aspects of cortical processing are associated with reporting musculoskeletal pain after a standardized peripheral muscle injury. CLINICAL SIGNIFICANCE: Cortical gray matter density of people without any pain may influence response to a standardized high intensity exercise protocol. This finding adds further support to the relevance of central factors in explaining the tremendous individual variability in pain report following acute musculoskeletal injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.