Evidence map›Paper›PMID 31479585›Full record

ArticleCytoskeleton (Hoboken, N.J.)2020

The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes.

Jennifer L Bocanegra, Barbara M Fujita, Natalie R Melton, James M Cowan, Elizabeth L Schinski, Tigist Y Tamir, Michael B Major, Omar A Quintero

Open access · greenAbstract read
In one paragraph

Article in Cytoskeleton (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  12. Review
  13. The multiple links between actin and mitochondria.Nature reviews. Molecular cell biology · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Miro proteins and their role in mitochondrial transfer in cancer and beyond.Frontiers in cell and developmental biology · 2022
    Review
  20. Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jennifer L BocanegraDepartment of Biology, University of Richmond, Richmond, Virginia.
Barbara M FujitaDepartment of Biology, University of Richmond, Richmond, Virginia.
Natalie R MeltonDepartment of Biology, University of Richmond, Richmond, Virginia.
James M CowanDepartment of Biology, University of Richmond, Richmond, Virginia.
Elizabeth L SchinskiDepartment of Biology, University of Richmond, Richmond, Virginia.
Tigist Y TamirDepartment of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina.
Michael B MajorDepartment of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-6753-8513
Omar A QuinteroDepartment of Biology, University of Richmond, Richmond, Virginia.ORCID 0000-0002-9314-1704
University of Richmond · USUniversity of North Carolina at Chapel Hill · US

Funding

Myosin-XIX and the molecular mechanism of actin-based mitochondrial organizationR15GM119077 · NIGMS · UNIVERSITY OF RICHMOND · PI QUINTERO-CARMONA, OMAR ALBERTO · 2016 to 2017
$548k
NIGMS NIH HHS R15 GM119077
6 · The paper itself

Abstract

MYO19 interacts with mitochondria through a C-terminal membrane association domain (MyMOMA). Specific mechanisms for localization of MYO19 to mitochondria are poorly understood. Using promiscuous biotinylation data in combination with existing affinity-capture databases, we have identified a number of putative MYO19-interacting proteins. We chose to explore the interaction between MYO19 and the mitochondrial GTPase Miro2 by expressing mchr-Miro2 in combination with GFP-tagged fragments of the MyMOMA domain and assaying for recruitment of MYO19-GFP to mitochondria. Coexpression of MYO19

Indexed as

HumansMitochondriaMitochondrial MembranesMyosinsProtein BindingProtein DomainsMyo19 protein, humanMyosinsGTPaseMiromitochondriamyosinouter membrane

Identifiers

PMID31479585
PMCPMC8556674
OpenAlexW2971418655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.