ArticleJournal of biophotonics2020
Phase dual-slopes in frequency-domain near-infrared spectroscopy for enhanced sensitivity to brain tissue: First applications to human subjects.
Article in Journal of biophotonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- OptoCENTAL: a standardized, bench-testing platform based on phantoms for validating optical systems aimed at clinical monitoring of the placenta.Journal of biomedical optics · 2026Article
- Functional dual-slope frequency-domain near-infrared spectroscopy data interpreted with two- and three-layer models.Biophotonics discovery · 2026Article
- Article
- Noninvasive measurements of skeletal muscle hemodynamics using frequency-domain near-infrared spectroscopy: contributions from adipose and bone tissues.Biophotonics discovery · 2025Article
- Influence of Uncertainties in Optode Positions on Self-Calibrating or Dual-Slope Diffuse Optical Measurements.Photonics · 2025Article
- Block-Wise Domain Adaptation for Workload Prediction from fNIRS Data.Sensors (Basel, Switzerland) · 2025Article
- Frequency-domain instrument with custom ASIC for dual-slope near-infrared spectroscopy.The Review of scientific instruments · 2024Article
- Spatial Sensitivity to Absorption Changes for Various Near-Infrared Spectroscopy Methods: A Compendium Review.Journal of innovative optical health sciences · 2024Article
- Dual-ratio approach to pulse oximetry and the effect of skin tone.Journal of biomedical optics · 2024Article
- Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics.Journal of biomedical optics · 2023Article
- Article
- Dual-ratio approach for detection of point fluorophores in biological tissue.Journal of biomedical optics · 2023Article
- Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy.Neurophotonics · 2023Article
- Method for Measuring Absolute Optical Properties of Turbid Samples in a Standard Cuvette.Applied sciences (Basel, Switzerland) · 2022Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- Broadband diffuse optical spectroscopy of two-layered scattering media containing oxyhemoglobin, deoxyhemoglobin, water, and lipids.Journal of innovative optical health sciences · 2022Article
- Investigation of effect of modulation frequency on high-density diffuse optical tomography image quality.Neurophotonics · 2021Article
- Broadband absorption spectroscopy of heterogeneous biological tissue.Applied optics · 2021Article
- Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography.Journal of biomedical optics · 2021Article
- Dual-Slope Diffuse Reflectance Instrument for Calibration-Free Broadband Spectroscopy.Applied sciences (Basel, Switzerland) · 2021Article
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5 authors.
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Abstract
We present a first in vivo application of phase dual-slopes (DSϕ), measured with frequency-domain near-infrared spectroscopy on four healthy human subjects, to demonstrate their enhanced sensitivity to cerebral hemodynamics. During arterial blood pressure oscillations elicited at a frequency of 0.1 Hz, we compare three different ways to analyze either intensity (I) or phase (ϕ) data collected on the subject's forehead at multiple source-detector distances: Single-distance, single-slope and DS. Theoretical calculations based on diffusion theory show that the method with the deepest maximal sensitivity (at about 11 mm) is DSϕ. The in vivo results indicate a qualitative difference of phase data (especially DSϕ) and intensity data (especially single-distance intensity [SDI]), which we assign to stronger contributions from scalp hemodynamics to SDI and from cortical hemodynamics to DSϕ. Our findings suggest that scalp hemodynamic oscillations may be dominated by blood volume dynamics, whereas cortical hemodynamics may be dominated by blood flow velocity dynamics.
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