Evidence map›Paper›PMID 31479529›Full record

ArticleCancer2019

Diagnostic colonoscopy completion after abnormal fecal immunochemical testing and quality of tests used at 8 Federally Qualified Health Centers in Southern California: Opportunities for improving screening outcomes.

Balambal Bharti, Folasade Fola Popoola May, Jesse Nodora, María Elena Martínez, Karina Moyano, Shauntay L Davis, Christian B Ramers, Felipe Garcia-Bigley, Shawne O'Connell, Kevin Ronan and 7 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06929481 (Screening With Liquid Biopsies to Address Colorectal Cancer Inequities), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06929481 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Screening With Liquid Biopsies to Address Colorectal Cancer Inequities

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2026Enrolled340ConditionsColorectal Cancer Screening, Colorectal Cancer (CRC)ArmsCell free DNA (cfDNA) blood test, At home Fecal Immunochemical Test (FIT) or Colonoscopy
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
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  7. Effectiveness and Cost of an Enhanced Mailed Fecal Test Outreach Colorectal Cancer Screening Program: Findings from the PROMPT Stepped-Wedge Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Trial
  8. Article
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  11. Article
  12. Article
  13. Article
  14. Review
  15. Response to Hu, Yang, and Sun.Journal of the National Cancer Institute · 2025
    Article
  16. Optimal Approach to Colorectal Cancer Screening.Gastroenterology & hepatology · 2025
    Article
  17. Article
  18. Developing Patient-Refined Messaging for Follow-Up Colonoscopy After Abnormal Fecal Testing in Hispanic Communities: Key Learnings from Virtual Boot Camp Translation.Hispanic health care international : the official journal of the National Association of Hispanic Nurses · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 1 country.

Balambal BhartiUniversity of California San Diego, La Jolla, California.
Folasade Fola Popoola MayJonsson Comprehensive Cancer Center and Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Jesse NodoraUniversity of California San Diego, La Jolla, California.
María Elena MartínezUniversity of California San Diego, La Jolla, California.ORCID 0000-0002-6728-1834
Karina MoyanoAmerican Cancer Society, San Diego, California.
Shauntay L DavisCalifornia Department of Public Health, Sacramento, California.
Christian B RamersUniversity of California San Diego, La Jolla, California.
Felipe Garcia-BigleyFamily Health Centers of San Diego, San Diego, California.
Shawne O'ConnellSan Ysidro Health, San Diego, California.
Kevin RonanVista Community Clinic, Vista, California.
Melissa BarajasNeighborhood Health Care, Escondido, California.
Sheree GordonTo Help Everyone Health and Wellness Centers, Los Angeles, California.
Giselle DiazNortheast Valley Health Center, Los Angeles, California.
Evelyn CejaSouth Central Family Health Center, Los Angeles, California.
Meghan PowersVenice Family Clinic, Venice, California.
Elva M ArredondoSan Diego State University, San Diego, California.
Samir GuptaUniversity of California San Diego, La Jolla, California.ORCID 0000-0003-4192-5002
University of California San Diego · USAmerican Cancer Society · USCalifornia Department of Public Health · USFamily Health Centers of San Diego · USLos Angeles Valley College · USNeighborhood Health · USSan Diego State University · USSan Ysidro Health · USSouth Central Family Health Center · USTo Help Everyone Health and Wellness Centers · USUniversity of California, Los Angeles · USVenice Family Clinic · USVista Community Clinic · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Research Education CoreU54CA132384 · NCI · SAN DIEGO STATE UNIVERSITY · PI CRIPPS, RICHARD MATTHEW, CROWE, SHEILA E. · 2008 to 2022
$20.7M
Supporting African American Churches to Promote Cancer ScreeningU54CA143931 · NCI · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI VADGAMA, JAYDUTT V. · 2009 to 2022
$19.7M
Research Education CoreU54CA132379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARREDONDO, ELVA M, CROWE, SHEILA E. · 2008 to 2021
$16.1M
CDC HHSCharles Drew Univeristy (CDU)-UCLA Partnership to Eliminate Cancer Disparities Grant U54CA143931Charles Drew University-University of California Los Angeles U54CA143931National Institute of Health U54CA132379National Institute of Health U54CA132384National Institute of Health (NIH) U54CA132379National Institute of Health (NIH) U54CA132384NCCDPHP CDC HHS U58 DP003862NCI NIH HHS P30 CA023100NCI NIH HHS U54 CA132379NCI NIH HHS U54 CA132384NCI NIH HHS U54 CA143931Specialized Cancer Center Support Grant to the UC San Diego Moores Cancer Center CA023100-32University of California San Diego Moores Cancer Center CA023100-32
6 · The paper itself

Abstract

backgroundThe effectiveness of colorectal cancer screening with fecal immunochemical tests (FITs) of stool blood depends on high rates of colonoscopy follow-up for abnormal FITs and the use of high-quality tests. This study characterized colonoscopy referral and completion among patients with abnormal FITs and the types of FITs implemented in a sample of Southern California Federally Qualified Health Centers (FQHCs).

methodsFQHCs in San Diego, Imperial, and Los Angeles Counties were invited to define a cohort of ≥150 consecutive patients with abnormal FITs in 2015-2016 and to provide data on sex, insurance status, diagnostic colonoscopy referrals and completion within 6 months of abnormal FITs, and the types (brands) of FITs implemented. The primary outcomes were the proportions with colonoscopy referrals and completion for all patients at each FQHC and in aggregate.

resultsEight FQHCs provided data for 1229 patients with abnormal FITs; 46% were male, and 20% were uninsured. Among patients with abnormal FITs, 89% (1091 of 1229; 95% confidence interval [CI], 0.87-0.91) had a colonoscopy referral, and 44% (539 of 1229; 95% CI, 0.41-0.47) had colonoscopy completion. Across FQHCs, the range for colonoscopy referral was 73% to 96%, and the range for completion was 18% to 57%. Six of the 8 FQHCs (75%) reported FIT brands with limited data to support their effectiveness.

conclusionsIn a sample of Southern California FQHCs, diagnostic colonoscopy completion after abnormal FITs was substantially below the nationally recommended benchmark to achieve 80% completion, and the use of FIT brands with limited data to support their effectiveness was high. These findings suggest a need for policies and multilevel interventions to promote diagnostic colonoscopy among individuals with abnormal FITs and the use of higher quality FITs.

Indexed as

AdolescentAdultCaliforniaColonoscopyColorectal NeoplasmsCross-Sectional StudiesEarly Detection of CancerFecesFemaleHumansImmunochemistryMaleMiddle AgedTreatment OutcomeYoung Adultabnormal fecal immunochemical test (FIT)colorectal cancerFederally Qualified Health CenterHispanicscreening

Identifiers

PMID31479529
PMCPMC7008958
OpenAlexW2971697340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.