Evidence map›Paper›PMID 31479526›Full record

ArticleClinical endocrinology2019

Exploring the link between tumour metabolism and succinate dehydrogenase deficiency: A

Thibaut Reichert, Nicolas Fakhry, Jean-Pierre Lavieille, Vincent Amodru, Frédéric Sebag, Pauline Romanet, Anderson Loundou, Frédéric Castinetti, Karel Pacak, Marion Montava and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. DecipheringJournal of endocrinological investigation · 2025
    Article
  2. Contemporary management of paragangliomas of the head and neck.Laryngoscope investigative otolaryngology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Thibaut ReichertDepartment of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.
Nicolas FakhryDepartment of Head and Neck Surgery, Conception Hospital, Aix-Marseille Univ, Marseille, France.
Jean-Pierre LavieilleDepartment of Head and Neck Surgery, Conception Hospital, Aix-Marseille Univ, Marseille, France.
Vincent AmodruDepartment of Endocrinology, Conception University Hospital, Aix-Marseille University, Marseille, France.
Frédéric SebagDepartment of Endocrine Surgery, Conception University Hospital, Aix-Marseille University, Marseille, France.
Pauline RomanetLaboratory of Molecular Biology, Conception Hospital & CNRS, CRN2M UMR 7286, Aix-Marseille University, Marseille, France.
Anderson LoundouDepartment of Public Health, EA3279 Self-perceived Health Assessment Research Unit, Aix-Marseille University, Marseille, France.
Frédéric CastinettiDepartment of Endocrinology, Conception University Hospital, Aix-Marseille University, Marseille, France.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD, USA.
Marion MontavaDepartment of Head and Neck Surgery, Conception Hospital, Aix-Marseille Univ, Marseille, France.
David TaïebDepartment of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.ORCID 0000-0002-0400-7600
Aix-Marseille Université · FRHôpital de la Conception · FRCentre National de la Recherche Scientifique · FRNational Institutes of Health · US

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD008735
6 · The paper itself

Abstract

objectivesNuclear imaging findings by virtue of phenotyping disease heavily depend on genetic background, metabolites, cell membrane specific targets and signalling pathways. PPGL related to succinate dehydrogenase subunits mutations (SDHx mutations) are less differentiated than other subgroups and therefore may lack to concentrate

designRetrospective study PATIENTS: A cohort of 86 head and neck PPGL patients (including three metastatic) with normal metanephrines underwent

resultsIn nonmetastatic HNPGL (50 non-SDHx/33 SDHx), no significant difference was observed between these two groups for SUVmax (P = .256), SUVmean (P = .188), MTV 42% (P = .596) and total lesion uptake (P = .144). Metastatic HNPGL also had high elevated uptake values.

conclusionsOur results suggest that SDH deficiency or metastatic behaviour have no influence on

Indexed as

AdultFemaleGenotypeHead and Neck NeoplasmsHumansMaleMiddle AgedMutationParagangliomaPositron Emission Tomography Computed TomographyRadionuclide ImagingRetrospective StudiesSuccinate DehydrogenaseSuccinate Dehydrogenase18F-FDOPAgeneticsparagangliomasradionuclide imagingsuccinate dehydrogenase

Identifiers

PMID31479526
PMCPMC7446860
OpenAlexW2971923490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.