Evidence map›Paper›PMID 31479421›Full record

ArticleAging2019

Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis.

Xiaohao Zhang, Pengyu Gong, Lei Sheng, Yanni Lin, Qiqi Fan, Yun Zhang, Yuanfei Bao, Shizhan Li, Hongcai Du, Zhonglun Chen and 8 more

Abstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xiaohao ZhangDepartment of Neurology, Jiangsu Provincial Second Chinese Medicine Hospital, Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Pengyu GongDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Lei ShengDepartment of Neurology, Jiangsu Provincial Second Chinese Medicine Hospital, Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yanni LinDepartment of Neurology, The First People's Hospital of Yulin, Yulin, Guangxi, China.
Qiqi FanDepartment of Neurology, Jiangsu Provincial Second Chinese Medicine Hospital, Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yun ZhangDepartment of Neurology, Mianyang Central Hospital, Mianyang, Sichuan, China.
Yuanfei BaoDepartment of Neurology, The Third People's Hospital of Nantong, Nantong, Jiangsu, China.
Shizhan LiDepartment of Neurology, The First People's Hospital of Yulin, Yulin, Guangxi, China.
Hongcai DuDepartment of Neurology, Mianyang Central Hospital, Mianyang, Sichuan, China.
Zhonglun ChenDepartment of Neurology, Mianyang Central Hospital, Mianyang, Sichuan, China.
Caixia DingDepartment of Neurology, Jiangsu Provincial Second Chinese Medicine Hospital, Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Huaiming WangDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Pengfei XuDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Min ZhangDepartment of Endocrinology, Nanjing Xianlin Drum Tower Hospital, Nanjing, Jiangsu, China.
Fabien ScalzoDepartment of Neurology, Neurovascular Imaging Research Core, University of California Los Angeles, Los Angeles, CA 90095, USA.
David S LiebeskindDepartment of Neurology, Neurovascular Imaging Research Core, University of California Los Angeles, Los Angeles, CA 90095, USA.
Yi XieDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Dezhi LiuDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data regarding the association between subclinical thyroid dysfunction and clinical outcomes in ischemic stroke patients with intravenous thrombolysis (IVT) are limited. We aimed to investigate the predictive value of subclinical thyroid dysfunction in END, functional outcome and mortality at 3 months among IVT patients. We prospectively recruited 563 IVT patients from 5 stroke centers in China. Thyroid function status was classified as subclinical hypothyroidism, subclinical hyperthyroidism (SHyper) and euthyroidism. The primary outcome was END, defined as ≥ 4 point in the NIHSS score within 24 h after IVT. Secondary outcomes included 3-month functional outcome and mortality. Of the 563 participants, END occurred in 14.7%, poor outcome in 50.8%, and mortality in 9.4%. SHyper was an independent predictor of END [odd ratio (OR), 4.35; 95% confidence interval [CI], 1.86-9.68,

Indexed as

AgedCohort StudiesFemaleFibrinolytic AgentsHumansMaleMiddle AgedPrognosisProspective StudiesStrokeThrombolytic TherapyThyroid DiseasesTreatment OutcomeFibrinolytic Agentsearly neurological deteriorationischemic strokesubclinical hyperthyroidismsubclinical hypothyroidismthrombolysis

Identifiers

PMID31479421
PMCPMC6756908

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.