ArticleMenopause (New York, N.Y.)2020
Long-term risk of de novo mental health conditions after hysterectomy with ovarian conservation: a cohort study.
Article in Menopause (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biopsychosocial profile of women with pelvic organ prolapse: A systematic review.Women's health (London, England)Pooled it
- [Uterine fibroids-Minimally invasive treatment with embolization].Radiologie (Heidelberg, Germany) · 2026Review
- Menopause and neurological disorders: a roadmap for research.Nature reviews. Neurology · 2026Review
- Fibroids and health disparities: the COllaboration for EQuity in Uterine Leiomyomas specialized center.American journal of obstetrics and gynecology · 2026Article
- BRCA1 and BRCA2 carriers: Perceptions of endometrial cancer risk.Gynecologic oncology · 2026Article
- Breaking the Cycle: A Case of Delayed Diagnosis and Sustained Remission Following Definitive Surgical Treatment of Premenstrual Dysphoric Disorder (PMDD).Case reports in psychiatry · 2026Article
- Prevalence of depression & anxiety in post-hysterectomy women & their association with quality of life: A cross-sectional hospital-based study.The Indian journal of medical research · 2025Article
- Applying Parse's Theory in Caring for a Depressed Patient Following Hysterectomy With Oophorectomy: A Case Study.Cancer reports (Hoboken, N.J.) · 2025Article
- Endometriosis: A Review.JAMA · 2025Review
- Evaluation of the In Vivo Efficacy of the JAK Inhibitor AZD1480 in Uterine Leiomyomas Using a Patient-derived Xenograft Murine Model.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- The Quality of Life beafore and after Hysterectomy in Premenopausal Women : Quality of Life in Women Before and After Hysterectomy.Galen medical journal · 2025Article
- Latent profiles of post-traumatic growth in patients with recent hysterectomy: psychosocial predictors and stigma-associated outcomes.Frontiers in psychiatry · 2025Article
- Risks of Long-Term Psychiatric Disease in Women with a History of Primary Infertility: A Historical Cohort Study.The Psychiatric quarterly · 2024Article
- Association between hysterectomy and kidney stone disease: results from the National Health and Nutrition Examination Survey 2007-2018 and Mendelian randomization analysis.World journal of urology · 2023Observational
- Correlation analysis of hysterectomy and ovarian preservation with depression.Scientific reports · 2023Article
- Overtreatment by hysterectomy for cervical intraepithelial neoplasia: Medico-legal aspects.International journal of reproductive biomedicine · 2023Article
- Women With a History of Primary Infertility and Increased Rates of Bilateral Oophorectomy.Obstetrics and gynecology · 2022Article
- Adverse childhood experiences are associated with increased risk of hysterectomy and bilateral oophorectomy: A national retrospective cohort study of women in England.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Incidence and determinants of hysterectomy among North Indian women: An 8-year follow-up study.Frontiers in public health · 2022Article
- Uterine fibroids and incidence of depression, anxiety and self-directed violence: a cohort study.Journal of epidemiology and community health · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe aim of this research was to study the long-term risk of de novo mental health conditions in women who underwent hysterectomy with bilateral ovarian conservation compared with age-matched referent women.
methodsUsing the Rochester Epidemiology Project records-linkage system, we identified a historical cohort of 2,094 women who underwent hysterectomy with ovarian conservation for benign indications at age ≥18 years and with an index date between 1980 and 2002 in Olmsted County, Minnesota. Each woman was age-matched (±1 y) to a referent woman residing in the same county who had not undergone hysterectomy or any oophorectomy before the index date. These two cohorts were followed historically to identify de novo mental health conditions. We estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) using Cox proportional hazards models adjusted for 20 preexisting chronic conditions and other potential confounders. We also calculated absolute risk increases (ARIs) and reductions (ARRs) at 30 years of follow-up.
resultsOver a median follow-up of 21.9 years, women who underwent hysterectomy at any age experienced increased risks of de novo depression (adjusted HR 1.26; 95% CI, 1.12-1.41; ARI 6.6%) and anxiety (adjusted HR 1.22; 95% CI, 1.08-1.38; ARI 4.7%). The association for depression increased significantly with younger age at hysterectomy, but did not vary significantly by indication. Interactions were not significant for anxiety.
conclusionsHysterectomy, even with ovarian conservation, is associated with an increased long-term risk of de novo depression and anxiety, especially when performed in women who are younger. : Video Summary:http://links.lww.com/MENO/A465.
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