ArticleeLife2019
Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- The planktonic microbiome of the Great Barrier Reef.Nature · 2026Article
- Site-specialization of human oralbioRxiv : the preprint server for biology · 2026Article
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- From microbial diversity to functional potential using dimensionality reduction.Frontiers in microbiology · 2026Article
- New SAR11 isolate genomes and global marine metagenomes resolve ecologically relevant units within the Pelagibacterales.Nature communications · 2025Article
- Ecogenomics and functional biogeography of the Roseobacter group in the global oceans based on 653 MAGs and SAGs.Microbiome · 2025Article
- A genomic atlas of the human gut virome elucidates genetic factors shaping host interactions.bioRxiv : the preprint server for biology · 2025Article
- Genome-resolved biogeography of Phaeocystales, cosmopolitan bloom-forming algae.Nature communications · 2025Article
- Article
- Ecophysiology and global dispersal of the freshwater SAR11-IIIb genus Fontibacterium.Nature microbiology · 2025Article
- Bringing the uncultivated microbial majority of freshwater ecosystems into culture.Nature communications · 2025Article
- Large diversity in the O-chain biosynthetic cluster within populations of Pelagibacterales.mBio · 2025Article
- Extensive paralogism in the environmental pangenome: a key factor in the ecological success of natural SAR11 populations.Microbiome · 2025Article
- Habitat-specificity in SAR11 is associated with a few genes under high selection.The ISME journal · 2025Article
- Promiscuous and genome-wide recombination underlies the sequence-discrete species of the SAR11 lineage in the deep ocean.The ISME journal · 2025Article
- SAR11 ecotypes across ocean basins change with depth due to changes in light and oxygen.The ISME journal · 2025Article
- Marine phytoplankton impose strong selective pressures onISME communications · 2025Article
- Two decades of bacterial ecology and evolution in a freshwater lake.Nature microbiology · 2025Article
- Uneven sequencing (coverage) depth can bias microbial intraspecies diversity estimates and how to account for it.ISME communications · 2025Article
- Review
15 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Members of the SAR11 order Pelagibacterales dominate the surface oceans. Their extensive diversity challenges emerging operational boundaries defined for microbial 'species' and complicates efforts of population genetics to study their evolution. Here, we employed single-amino acid variants (SAAVs) to investigate ecological and evolutionary forces that maintain the genomic heterogeneity within ubiquitous SAR11 populations we accessed through metagenomic read recruitment using a single isolate genome. Integrating amino acid and protein biochemistry with metagenomics revealed that systematic purifying selection against deleterious variants governs non-synonymous variation among very closely related populations of SAR11. SAAVs partitioned metagenomes into two main groups matching large-scale oceanic current temperatures, and six finer proteotypes that connect distant oceanic regions. These findings suggest that environmentally-mediated selection plays a critical role in the journey of cosmopolitan surface ocean microbial populations, and the idea 'everything is everywhere but the environment selects' has credence even at the finest resolutions.
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