ArticleRadiology2019
Myeloperoxidase Molecular MRI Reveals Synergistic Combination Therapy in Murine Experimental Autoimmune Neuroinflammation.
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Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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4citing papers in PubMed, 1 pooled it
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation.Cells · 2022Pooled it
- Complementary PET and MRI of myeloperoxidase activity as a noninvasive surrogate for tissue acrolein in experimental neuroinflammation.NeuroImage · 2026Article
- Basic Science of Neuroinflammation and Involvement of the Inflammatory Response in Disorders of the Nervous System.Magnetic resonance imaging clinics of North America · 2024Review
- Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy.Journal for immunotherapy of cancer · 2021Article
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Authors and funding
11 authors.
Anning LiFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
Yue WuFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
Benjamin PulliFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
Gregory R WojtkiewiczFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).ORCID 0000-0002-3148-8411
Yoshiko IwamotoFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).ORCID 0000-0002-3723-1043
Cuihua WangFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).ORCID 0000-0003-3417-6947
Jing-Hui LiFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).ORCID 0000-0002-5095-3921
Muhammad AliFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
Xiaoyuan FengFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).ORCID 0000-0003-4525-7494
Zhenwei YaoFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).ORCID 0000-0002-5681-4308
John W ChenFrom the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).ORCID 0000-0001-7388-9590
Funding
Imaging macrophage and microglial functional diversity in strokeR01NS103998 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JOHN W · 2018 to 2022
$2.6MMyeloperoxidase, imaging biomarker and treatment target for multiple sclerosisR01NS070835 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JOHN W · 2010 to 2014
$1.9MNINDS NIH HHS R01 NS070835NINDS NIH HHS R01 NS103998
Abstract
Background Despite advances in immunomodulatory agents, most current therapies for multiple sclerosis target lymphocytes or lymphocytic function. However, therapy response may be less than optimal due to demyelination and axonal damage caused by myeloid cells. Purpose To determine if myeloperoxidase (MPO) molecular MRI can evaluate whether combination therapy targeting both lymphoid and myeloid inflammation can improve autoimmune neuroinflammation compared with either drug alone, even at suboptimal doses. Materials and Methods Four groups of 94 female mice (8-10 weeks old) were induced with experimental autoimmune encephalomyelitis (EAE) from August 2, 2016, to March 30, 2018, and divided into saline control (
Indexed as
Aniline CompoundsAnimalsBrainContrast MediaDisease Models, AnimalDrug Therapy, CombinationEncephalomyelitis, Autoimmune, ExperimentalFemaleGadoliniumGlatiramer AcetateImage EnhancementImmunosuppressive AgentsMagnetic Resonance ImagingMicePeroxidaseSaline Solution4-aminobenzhydrazideAniline CompoundsContrast MediaGadoliniumGlatiramer AcetateImmunosuppressive AgentsPeroxidaseSaline Solution
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.