ArticleThe journal of physical chemistry. A2019
Direct Observation of Intrachain Hydrogen Bonds in Aqueous Hyaluronan.
Article in The journal of physical chemistry. A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Assessment of Hydrogels for Intra-Articulate Application, Based on Sodium Hyaluronate Doped with Synthetic Polymers and Incorporated with Diclofenac Sodium.International journal of molecular sciences · 2025Article
- The Effects of Synthetic Polymers on the Release Patterns of Bupivacaine Hydrochloride from Sodium Hyaluronate Hydrogels.Biomedicines · 2024Article
- Photoinduced Dithiolane Crosslinking for Multiresponsive Dynamic Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine?International journal of molecular sciences · 2024Review
- Determination of Amide cis/trans Isomers in N-Acetyl-d-glucosamine: Tailored NMR Analysis of the N-Acetyl Group Conformation.Chembiochem : a European journal of chemical biology · 2022Article
- Article
- Molecular Structure and Surface Accumulation Dynamics of Hyaluronan at the Water-Air Interface.Macromolecules · 2021Article
- Disaccharide Residues are Required for Native Antifreeze Glycoprotein Activity.Biomacromolecules · 2021Article
- Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer.Biomedicines · 2021Article
- Connecting the Stimuli-Responsive Rheology of Biopolymer Hydrogels to Underlying Hydrogen-Bonding Interactions.Macromolecules · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We use two-dimensional infrared spectroscopy to study the interactions between the amide and carboxylate anion groups of hyaluronan polymers at neutral pH. The spectra reveal the presence of intrachain hydrogen bonds between the amide and carboxylate anion groups in aqueous solution. We determine the relative orientation of the amide and carboxylate anion groups when forming this hydrogen bond and quantify the fraction of amide groups that participate in hydrogen bonding. We find that a variation of the pH and/or temperature has a negligible effect on this fraction, whereas the persistence length of the hyaluronan chains and the associated viscosity of hyaluronan solutions are known to change significantly. We conclude that the hydrogen bonding between the amide and carboxylate anion groups does not significantly contribute to the chain rigidity of hyaluronan polymers.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.