ArticleBritish journal of pharmacology2020
Lasting effects of repeated ∆
Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 67 citations in OpenAlex.
- Sex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC).Psychopharmacology · 2022Trial
- Persistent effects of repeated adolescent and adult heroin vapor inhalation in female Wistar rats.Psychopharmacology · 2026Article
- Innovative Methods for Prenatal Cannabis Exposure: Vapor Inhalation Chamber and Metabolite Quantification in Prairie Voles and Rats.Developmental psychobiology · 2026Article
- Impact of sex on heroin intravenous self-administration by heterogeneous stock rats.Psychopharmacology · 2026Article
- Impact of Age on Heroin Intravenous Self-Administration in Wistar Rats.bioRxiv : the preprint server for biology · 2026Article
- Impact of Sex on Heroin Intravenous Self-Administration by Heterogeneous Stock Rats.bioRxiv : the preprint server for biology · 2026Article
- Neurobehavioral Effects of "Dry Hit" Nicotine E-Cigarette Vapor Inhalation in Adolescent Wistar Rats.bioRxiv : the preprint server for biology · 2026Article
- Chronic ΔBritish journal of pharmacology · 2025Article
- Methamphetamine and α-pyrrolidinopentiophenone (α-PVP) intravenous self-administration in female and male rats.Psychopharmacology · 2025Article
- Methamphetamine and α-pyrrolidinopentiophenone (α-PVP) Intravenous Self-Administration in Female and Male Rats.bioRxiv : the preprint server for biology · 2025Article
- Assessment of the associative determinants of tolerance to the effects of cannabis extract on exploratory behavior in rats.Drug and alcohol dependence reports · 2025Article
- Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice.Psychopharmacology · 2025Article
- Sex Differences in Response-Contingent Cannabis Vapor Administration During Adolescence Mediate Enduring Effects on Behavioral Flexibility and Prefrontal Microglia Activation in Rats.Cannabis and cannabinoid research · 2024Article
- β-caryophyllene inhibits heroin self-administration, but does not alter opioid-induced antinociception in rodents.Neuropharmacology · 2024Article
- Adult Consequences of Repeated Nicotine Vapor Inhalation in Adolescent Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Adult consequences of repeated nicotine and ΔPsychopharmacology · 2024Article
- Sex Differences in E-Cigarette Use and Related Health Effects.International journal of environmental research and public health · 2023Review
- Sex differences in acute delta-9-tetrahydrocannabinol (ΔPsychopharmacology · 2023Article
- Mechanisms of cannabinoid tolerance.Biochemical pharmacology · 2023Review
- Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats.Psychopharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeAdolescents are regularly exposed to ∆ EXPERIMENTAL APPROACHES: Male and female rats inhaled THC vapour, or that from the propylene glycol (PG) vehicle, twice daily for 30 min from postnatal day (PND) 35-39 and PND 42-46 using an e-cigarette system. Thermoregulatory responses to vapour inhalation were assessed by radio-telemetry during adolescence and from PND 86-94. Chow intake was assessed in adulthood. Blood samples were obtained from additional adolescent groups following initial THC inhalation and after 4 days of twice daily exposure. Additional groups exposed repeatedly to THC or PG during adolescence were evaluated for intravenous self-administration of oxycodone as adults. KEY
resultsFemale, not male, adolescents developed tolerance to the hypothermic effects of THC inhalation in the first week of repeated exposure despite similar plasma THC levels. Each sex exhibited tolerance to THC hypothermia in adulthood after repeated adolescent THC. However, enhanced potency was found in females. Repeated THC male rats consumed more food than their PG-treated control group, without significant bodyweight differences. Adolescent THC did not alter oxycodone self-administration in either sex but increased fentanyl self-administration in females. CONCLUSIONS AND IMPLICATIONS: Repeated THC vapour inhalation in adolescent rats has lasting consequences observable in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.