ArticleHistology and histopathology2020
Comparison of the clinicopathological features of pancreatic solid pseudopapillary neoplasms between males and females: gender does matter.
Article in Histology and histopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Pancreatic solid pseudopapillary neoplasms in male patients exhibit different clinical and imaging features compared with those in female patients.Abdominal radiology (New York) · 2026Article
- Sex hormone receptor signaling networks drive pancreatic solid-pseudopapillary neoplasm pathogenesis and therapy.Discover oncology · 2025Review
- Pancreatic Solid Pseudopapillary Neoplasms-Clinicopathological Characteristics and Surgical Outcomes: A 10-Year Single-Centre Observational Study.Biomedicines · 2025Article
- Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas.World journal of gastrointestinal oncology · 2024Review
- A case of middle-aged male with multicentric solid pseudopapillary neoplasm of the pancreas.Clinical journal of gastroenterology · 2023Article
- Solid Pseudopapillary Neoplasm of the Pancreas: Unfolding an Intriguing Condition.GE Portuguese journal of gastroenterology · 2022Review
- The Sex Features of Patients With Solid Pseudopapillary Neoplasms of the Pancreas: A Retrospective Study.Frontiers in oncology · 2022Article
- Solid pseudopapillary neoplasm-diagnostic approach and post-surgical follow up: Three case reports and review of literature.World journal of clinical cases · 2021Article
- Molecular genetic changes in solid pseudopapillary neoplasms (SPN) of the pancreas.Acta oncologica (Stockholm, Sweden) · 2020Article
- Sex differences in solid pseudopapillary neoplasm of the pancreas: A population-based study.Cancer medicine · 2020Article
- A Review of Clinicopathological Characteristics and Treatment of Solid Pseudopapillary Tumor of the Pancreas with 2450 Cases in Chinese Population.BioMed research international · 2020Review
- Clinical manifestations and multi-slice computed tomography characteristics of solid pseudopapillary neoplasms of the pancreas between males and females.BMC medical imaging · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSolid pseudopapillary neoplasms (SPN) of the pancreas are a rare and low-grade malignant entity with a female predominance. However, it also occurs in males, but the rarity and lack of concern makes its clinicopathological features unclarified.
methodsThe morphological, immunohistochemical, prognostic features and CTNNB1 exon 3 mutation status of SPN were compared semi-quantitively between 9 male and 21 female patients.
resultsSPN in males grew in a distinctive solid pattern, with abundant fibrotic stroma and clear cells. Collagen tended to be the main component of tumor stroma in males, while hyaluronan composed a considerable proportion in females. A much stronger expression of androgen receptor (AR) was found in males, and CD56 and/or synaptophysin (Syn) was expressed frequently in both genders. All patients survived. One male patient had post-operational liver nodules and accepted interventional therapy without biopsy. Mutations of CTNNB1 exon 3 were observed in all cases, distributed at codon 32, 33 and 37 in both genders, as well as 34, 41 and 62 in females.
conclusionSPN in males presented with significantly different morphological features from that in females, which might be helpful in differential diagnosis, especially when with extensive positivity for CD56 and/or Syn. The stronger expression of AR in males might be a clue to explore the underlying mechanism of the gender difference.
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