ArticleMetabolic brain disease2019
Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD).
Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Severe Vitamin D Deficiency-A Possible Cause of Resistance to Treatment in Psychiatric Pathology.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Gut microbiota and the tryptophan-kynurenine pathway in anxiety: new insights and treatment strategies.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Can Vıtamın D Reduce the Need for SSRI by Modulatıng Serotonın Synthesıs?: A Revıew of Recent Lıterature.Current nutrition reports · 2025Review
- Harnessing precision nutrition to individualize weight restoration in anorexia nervosa.Journal of eating disorders · 2025Review
- Relationship between emotional eating and nutritional intake in adult women with overweight and obesity: a cross-sectional study.Nutrition journal · 2024Article
- Does vitamin D supplementation impact serotonin levels? A systematic review and meta-analysis.Health science reports · 2024Article
- Effectiveness of Vitamin D on Neurological and Mental Disorders.Diseases (Basel, Switzerland) · 2024Review
- Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour.Heliyon · 2024Article
- Association of serum vitamin D with anxiety in US adults: a cross-sectional study.Frontiers in nutrition · 2024Article
- Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders.Nutrients · 2023Review
- Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance.International journal of environmental research and public health · 2023Article
- Associations between Dietary Intake of Vitamin D, Sun Exposure, and Generalized Anxiety among College Women.Nutrients · 2022Article
- A High Dose, Not Low Dose, of Vitamin D Ameliorates Insulin Resistance in Saudi Women.Journal of clinical medicine · 2022Article
- Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety.International journal of molecular sciences · 2022Review
- Nutrition as Metabolic Treatment for Anxiety.Frontiers in psychiatry · 2021Article
- Low Prenatal Vitamin D Metabolite Ratio and Subsequent Postpartum Depression Risk.Journal of women's health (2002) · 2021Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effects of vitamin D supplementation on Generalized Anxiety Disorder (GAD) clinical symptoms and neurochemical biomarkers including serotonin, neopterin and kynurenine. Thirty male and female patients diagnosed with GAD and had vitamin D deficiency were recruited from the psychiatric clinic at King Abdulaziz University Hospital and divided into two groups; one group of patients (n = 15) received standard of care (SOC) plus 50,000 IU vitamin D (once/week) for 3 months, while the other group (n = 15) received SOC alone. Biochemical parameters including serum vitamin D, serotonin, neopterin and kynurenine were measured for all patients enrolled in the trial. In addition, the Generalized Anxiety Disorder 7-item (GAD-7) scale was used to measure the severity of GAD symptoms in both vitamin D treated- and untreated-patients. Significant improvements in GAD scores were observed in the vitamin D-treated group compared to the group that did not receive vitamin D. In addition, serum serotonin concentrations were significantly increased while serum neopterin were significantly decreased in vitamin D-treated vs. untreated patients. In contrast, no significant differences were found in serum kynurenine concentrations at the end of the study period between the two groups. No changes either in GAD-7 scores or in any of the biochemical measurements were observed in the group that received only SOC after 3 months. Vitamin D supplementation was effective in ameliorating the severity of GAD symptoms by increasing serotonin concentrations and decreasing the levels of the inflammatory biomarker neopterin in GAD patients.
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