Evidence map›Paper›PMID 31477925›Full record

ReviewNature biotechnology2019

Precision electronic medicine in the brain.

Shaun R Patel, Charles M Lieber

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Nature biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 93 citations in OpenAlex.

  1. Review
  2. Review
  3. An exceptionally conductive hydrogel for all-organic, ultraflexible, and chronic neural interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Article
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  8. Article
  9. Review
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  11. Review
  12. Article
  13. Article
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  15. Article
  16. Review
  17. Stitching Flexible Electronics into the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  18. Liquid Metal-Based Electrode Array for Neural Signal Recording.Bioengineering (Basel, Switzerland) · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shaun R PatelMcCance Center for Brain Health, Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. shaun.patel@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-9334-2522
Charles M LieberDepartment of Chemistry and Chemical Biology, Center for Brain Science, and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. cml@cmliris.harvard.edu.ORCID http://orcid.org/0000-0002-6660-2456
Harvard University · US

Funding

Syringe-Injectable Mesh Electronics for Seamless Integration with the Central Nervous SystemDP1EB025835 · NIBIB · HARVARD UNIVERSITY · PI LIEBER, CHARLES M · 2017 to 2019
$3.5M
NIBIB NIH HHS DP1 EB025835
6 · The paper itself

Abstract

Periodically throughout history developments from adjacent fields of science and technology reach a tipping point where together they produce unparalleled advances, such as the Allen Brain Atlas and the Human Genome Project. Today, research focused at the interface between the nervous system and electronics is not only leading to advances in fundamental neuroscience, but also unlocking the potential of implants capable of cellular-level therapeutic targeting. Ultimately, these personalized electronic therapies will provide new treatment modalities for neurodegenerative and neuropsychiatric illness; powerful control of prosthetics for restorative function in degenerative diseases, trauma and amputation; and even augmentation of human cognition. Overall, we believe that emerging advances in tissue-like electronics will enable minimally invasive devices capable of establishing a stable long-term cellular neural interface and providing long-term treatment for chronic neurological conditions.

Indexed as

Precision MedicineBrainCentral Nervous System DiseasesElectrophysiological PhenomenaHumansNanotechnology

Identifiers

PMID31477925
PMCPMC6741780
OpenAlexW2971385201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.