ArticleNature medicine2019
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR.
Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07502118 (An Open-Label, Multicenter Phase 2-3 Clinical Study of Anti-CD19 Chimeric Antigen Receptor T Cells), which is not on this map. Cited by 407 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
407citing papers in PubMed, 5 pooled it
30.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07502118 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation
An Open-Label, Multicenter Phase 2-3 Clinical Study of Anti-CD19 Chimeric Antigen Receptor T Cells (Talikabtagene Autoleucel) in Patients With Relapsed/Refractory B-Cell Malignancies (NexCAR19)
Who cites it
407 citing papers in PubMed, 5 syntheses or guidelines pooled it, 623 citations in OpenAlex.
- Mapping the clinical landscape of multifunctional CAR T cells: Targets, trends, and synergies.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Pooled it
- CAR T-cell therapy in patients with acute lymphoblastic leukemia: a systematic review and meta-analysis.Bone marrow transplantation · 2026Pooled it
- Comprehensive analysis of the efficacy and safety of CAR T-cell therapy in patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- Pooled it
- The synergistic immunotherapeutic impact of engineered CAR-T cells with PD-1 blockade in lymphomas and solid tumors: a systematic review.Frontiers in immunology · 2024Pooled it
- Trial
- CAR T-cell Kinetics, Persistence, and Clinical Outcomes in Adult Patients with Relapsed/Refractory B-cell ALL Treated with Obecabtagene Autoleucel in the FELIX Study.Cancer research communications · 2026Trial
- Trial
- Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia.The New England journal of medicine · 2024Trial
- Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing.The Journal of clinical investigation · 2024Trial
- Fine-tuning affinity and spacer design enhances T cell potency in DLL3 and BCMA CAR T cells.mAbs · 2026Article
- Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition.Molecular systems biology · 2026Article
- Super-resolution imaging reveals altered actin architecture at CAR-T cell immune synapses.The Journal of cell biology · 2026Article
- Multi-dimensional orchestration of binders for improved CAR-T immunotherapy.Cancer letters · 2026Review
- The EF1α promoter of cilta-cel drives a highly effective GZMKNature communications · 2026Article
- Quantitative Characterization of Innate and Adaptive Pharmacology of Allogeneic anti-CD20 Chimeric Antigen Receptor (CAR) Vδ1 γδ T cells using Multiscale Mechanistic Modeling.The AAPS journal · 2026Article
- Development of chimeric antigen receptors targeting the γδ T cell receptor.Molecular therapy. Oncology · 2026Article
- Sequence and structural determinants of efficacious de novo chimaeric antigen receptors.Nature biomedical engineering · 2026Article
- Incorporating Immunotherapies into the Evolving Standard of Care for Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.Paediatric drugs · 2026Review
- Quantifying target antigen-dependent CAR T-cell performance against AML.Cancer cell international · 2026Article
347 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
44 authors at 6 institutions in 1 country.
Sara GhorashianMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-1555-2946
Anne Marijn KramerMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Shimobi OnuohaAutolus Ltd, London, UK.
Gary WrightDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Jack BartramDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Rachel RichardsonMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Sarah J AlbonMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Joan Casanovas-CompanyMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Fernanda CastroCancer Research UK & UCL Cancer Trials Centre, London, UK.
Bilyana PopovaCancer Research UK & UCL Cancer Trials Centre, London, UK.
Krystle VillanuevaCancer Research UK & UCL Cancer Trials Centre, London, UK.
Jenny YeungMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Winston VetharoyMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Aleks GuvenelMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Patrycja A WawrzynieckaCancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0002-4209-2834
Leila MekkaouiAutolus Ltd, London, UK.ORCID http://orcid.org/0000-0001-8640-840X
Gordon Weng-Kit CheungCancer Institute, University College London, London, UK.
Danielle PinnerDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Jan ChuDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Giovanna LucchiniDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Juliana SilvaDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Oana CiocarlieDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Arina LazarevaDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Sarah InglottDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Kimberly C GilmourCell Therapy and Immunology laboratories, Great Ormond Street Hospital for Children, London, UK.
Gulrukh AhsanCell Therapy and Immunology laboratories, Great Ormond Street Hospital for Children, London, UK.
Mathieu FerrariAutolus Ltd, London, UK.ORCID http://orcid.org/0000-0001-8535-7348
Somayya ManzoorAutolus Ltd, London, UK.
Kim ChampionCancer Research UK & UCL Cancer Trials Centre, London, UK.
Tony BrooksUniversity College London Genomics, London, UK.
Andre LopesCancer Research UK & UCL Cancer Trials Centre, London, UK.
Allan HackshawCancer Research UK & UCL Cancer Trials Centre, London, UK.
Farzin FarzanehDepartment of Haematological Medicine, King's College London, London, UK.
Robert ChiesaDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Kanchan RaoDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Denise BonneyDepartment of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.
Sujith SamarasingheDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Nicholas GouldenDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Ajay VoraDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Paul VeysDepartments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.
Rachael HoughDepartment of Haematology, University College London Hospitals NHS Trust, London, UK.
Robert WynnDepartment of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.
Martin A PuleCancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0002-8347-9867
Persis J AmroliaMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK. Persis.Amrolia@gosh.nhs.uk.ORCID http://orcid.org/0000-0003-0480-3911
Great Ormond Street Hospital · GBCancer Research UK · GBAutolus (United Kingdom) · GBKing's College London · GBUniversity College London Hospitals NHS Foundation Trust · GBRoyal Manchester Children's Hospital · GB
Funding
Biotechnology and Biological Sciences Research Council BB/D014301/1Biotechnology and Biological Sciences Research Council BB/E005896/1Department of Health NIHR-RP-R3-12-001
Abstract
Chimeric antigen receptor (CAR)-modified T cells targeting CD19 demonstrate unparalleled responses in relapsed/refractory acute lymphoblastic leukemia (ALL)
Indexed as
Immunotherapy, AdoptiveAdolescentAntigens, CD19ChildChild, PreschoolExome SequencingHumansPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, Antigen, T-CellReceptors, Chimeric AntigenRecurrenceT-LymphocytesYoung AdultAntigens, CD19Receptors, Antigen, T-CellReceptors, Chimeric Antigen
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT07502118ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.