ArticleNature microbiology2019
Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut.
Abstract read
In one paragraph
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 257 papers.
0numbers the graph read from it
0cells of the map it votes in
257citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
257 citing papers in PubMed, 465 citations in OpenAlex.
- Testosterone administration partially modulates gut microbiota responses to severe energy deficit.American journal of physiology. Endocrinology and metabolism · 2026Trial
- Effect of Lacticaseibacillus casei LC2W Supplementation on Glucose Metabolism and Gut Microbiota in Subjects at High Risk of Metabolic Syndrome: A Randomized, Double-blinded, Placebo-controlled Clinical Trial.Probiotics and antimicrobial proteins · 2025Trial
- Trial
- Pediococcus acidilactici ZQ-19 Ameliorates Ulcerative Colitis via Remodeling Gut Microbiota and Glutathione Redox Homeostasis.Probiotics and antimicrobial proteins · 2026Article
- Drug-microbiome-host interactions: antimicrobial effects of non-antibiotic compounds.Nature reviews. Gastroenterology & hepatology · 2026Review
- Weight Gain During SSRI Therapy: The Potential Role of the Gut Microbiota-A Narrative Review and Mechanistic Hypothesis.Nutrients · 2026Review
- Distinctive spore architecture and developmental biology ofJournal of bacteriology · 2026Article
- Integrative microbiome and transcriptome analyses identify parity-associated alterations in rectal fecal microbiota and peripheral immune transcriptional signatures in dairy cows.BMC microbiology · 2026Observational
- The effect of SSRI/SNRI antidepressant treatment on the gut microbiota of patients with major depressive disorder.Communications medicine · 2026Article
- Article
- The microbiota-gut-brain axis: novel mechanisms and therapeutic frontiers in obesity and type 2 diabetes.NPJ biofilms and microbiomes · 2026Review
- Psychobiotic Effects of Postbiotics in Depression, Psychosis and Mania.Health promotion perspectives · 2026Review
- GV-971 Ameliorates Chronic Restraint Stress-Induced Depression-like Phenotypes Accompanied by Reshaping of the Microbiota-Gut-Brain Axis.Marine drugs · 2026Article
- Probiotics mitigate non-antibiotic drug-induced dysbiosis via protein homology-driven competitive binding.Nature communications · 2026Article
- Akkermansia Muciniphila vs. Fluoxetine: Amelioration of Depression-like Behaviors and Cognitive Dysfunction Through Distinct Neurobiological Mechanisms.Probiotics and antimicrobial proteins · 2026Article
- Gut-Brain Signaling in Parkinson's Disease: A Narrative Review.International journal of molecular sciences · 2026Review
- Multiomics-guided discovery of protective microbiome signatures in lupus-prone mice treated with Faecalibacterium prausnitzii.Nature communications · 2026Article
- Gut microbiome community structure correlates with different behavioral phenotypes in the Belyaev Farm-Fox Experiment.Communications biology · 2026Article
- Molecular mechanisms and therapeutic potential of tryptophan metabolism in gut-brain signaling transduction: a narrative review.Journal of neuroinflammation · 2026Review
- ProbioticJournal of animal science and technology · 2026Article
197 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Thomas C FungDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA. tcfung@g.ucla.edu.ORCID http://orcid.org/0000-0003-4405-3799
Helen E VuongDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Cristopher D G LunaDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Geoffrey N PronovostDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Antoniya A AleksandrovaComputational Structural Biology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Noah G RileyComputational Structural Biology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Anastasia VavilinaDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7692-1055
Julianne McGinnDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Tomiko RendonDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Lucy R ForrestComputational Structural Biology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1855-7985
Elaine Y HsiaoDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA. ehsiao@g.ucla.edu.ORCID http://orcid.org/0000-0002-1633-588X
University of California, Los Angeles · USNational Institutes of Health · US
Funding
Computational Studies of Membrane Transport ProteinsZIANS003139 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI FORREST, LUCY · 2014 to 2025
$13.7MMULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6MVascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4MUPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1MUncovering microbial modulators of neuroactive molecules as novel therapeutics.DP5OD017924 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAO, ELAINE · 2013 to 2017
$1.9MFunctional Role of IL-6 in Fetal Brain Development and Abnormal BehaviorF31MH090749 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HSIAO, ELAINE · 2011 to 2012
$64kNHLBI NIH HHS T32 HL069766NIAID NIH HHS T32 AI007323NIGMS NIH HHS K12 GM106996NIH HHS DP5 OD017924NIMH NIH HHS F31 MH090749
Abstract
The gut microbiota regulates levels of serotonin (5-hydroxytryptamine (5-HT)) in the intestinal epithelium and lumen
Indexed as
Administration, OralAnimalsBacillotaBacteriaFecesFemaleFluoxetineGastrointestinal MicrobiomeGenetic VariationHost Microbial InteractionsIntestinesMaleMiceMice, Inbred C57BLSelective Serotonin Reuptake InhibitorsSerotoninFluoxetineSelective Serotonin Reuptake InhibitorsSerotoninSerotonin Receptor Agonists
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.