ArticleJournal of human hypertension2020
Mediation effect of BMI on the relationship between age at menarche and hypertension: The Henan Rural Cohort Study.
Article in Journal of human hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Mendelian randomization study and meta-analysis exploring the causality of age at menarche and the risk of intracerebral hemorrhage and ischemic stroke.CNS neuroscience & therapeutics · 2023Pooled it
- Early menarche and late menopause and their association with hypertension among Bangladeshi women: a community-based cross-sectional study in Dhaka, Bangladesh.BMC women's health · 2026Article
- Early Menarche and Hypertension Among Postmenopausal Women: The Mediating Role of Obesity.Epidemiologia (Basel, Switzerland) · 2025Article
- Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.International journal of obesity (2005) · 2025Article
- Childhood obesity and central precocious puberty.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Long-term exposure to PMJournal of advanced research · 2024Article
- Adiposity indices and their higher predictive value for new-onset hypertension in metabolically healthy young women: findings from a population-based prospective cohort study.BMC cardiovascular disorders · 2024Article
- Association of age at menarche with gestational hypertension and preeclampsia: A large prospective cohort in China.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Late age at menopause positively associated with obesity-mediated hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Obesity indicators as mediators of the association between age at menopause and blood pressure values.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Mediation Effect of Obesity on the Association of Age at Menarche With Blood Pressure Among Women in Southwest China.Journal of the American Heart Association · 2023Article
- Article
- Associations between Age at Menarche and Dietary Patterns with Blood Pressure in Southwestern Chinese Adults.Nutrients · 2022Article
- Reproductive lifespan in association with risk of hypertension among Chinese postmenopausal women: Results from a large representative nationwide population.Frontiers in cardiovascular medicine · 2022Article
- Systolic blood pressure as the mediator of the effect of early menarche on the risk of coronary artery disease: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Ideal Cardiovascular Health Metrics Attenuated Association of Age at Menarche With Type 2 Diabetes in Rural China.International journal of public health · 2022Article
- A secular trend in age at menarche in Yunnan Province, China: a multiethnic population study of 1,275,000 women.BMC public health · 2021Article
- Age at menarche and risk of hypertension in Chinese adult women: Results from a large representative nationwide population.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were to explore the relationship of age at menarche with the incidence of hypertension in postmenopausal women and to examine whether the degree of obesity, as measured by body mass index (BMI), mediates the relationship. A total of 15361 postmenopausal women from the Henan Rural Cohort Study were included in this study. Subjects provided information on the age of menarche. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI). Mediation analysis was used to examine whether the association between age at menarche and hypertension was mediated by BMI, and calculate the proportion to which BMI contributed to this association. The means of the participant's age at menarche and age at recruitment were 16.1 and 61.5 years, respectively. Each 1-year increment in age at menarche was associated with a 3.0% decrease in the risk of hypertension. Compared with the middle quintile (16 years), those who were in the late menarche quintile (≥18 years) had a lower risk of hypertension (OR, 0.876; 95% CI, 0.788-0.975; P = 0.015) after adjusting for age at recruitment, menopausal age, parity, and other potential confounders. The OR (95% CI) of a significant indirect effect of BMI on the age at menarche-hypertension association was 0.977 (0.973-0.981; P = 0.0020). Women with a history of late menarche had a lower risk of hypertension. BMI mediated the effect of age at menarche on hypertension.
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