SynthesisNature communications2019
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
14.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.PLoS genetics · 2023Pooled it
- Genetic effects on the timing of parturition and links to fetal birth weight.Nature genetics · 2023Pooled it
- Pooled it
- Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight.International journal of epidemiology · 2021Pooled it
- Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus.BMC genomics · 2026Article
- Spatial Logic and Evolutionary Innovation in Human Placentation.bioRxiv : the preprint server for biology · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- Maternal health and autism risk: parsing direct and indirect genetic effects using 3-generation family linkage.medRxiv : the preprint server for health sciences · 2026Article
- Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026Article
- Comparative Single-Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Autism Heterogeneity Related to Preterm Birth: Multi-Ancestry Results From the Simons Foundation Powering Autism Research for Knowledge Sample.Biological psychiatry global open science · 2026Article
- Causal effects of maternal BMI on pregnancy outcomes: a Mendelian randomisation study investigating the mediating role of blood counts.Frontiers in genetics · 2026Article
- Genetically Causal Associations Between Adenomyosis/Endometriosis and Adverse Pregnancy Outcomes - A Two-Sample Mendelian Randomization Study.International journal of women's health · 2026Article
- Genomic approaches to understanding pregnancy phenotypes and birth outcomes and their links with long-term maternal and offspring health-the value of distinguishing maternal and fetal genetic effects.Frontiers in genetics · 2026Review
- Prematurity and genetic liability for autism spectrum disorder.Genome medicine · 2025Article
- Prematurity and Genetic Liability for Autism Spectrum Disorder.medRxiv : the preprint server for health sciences · 2025Article
- The genetics of low and high birthweight and their relationship with cardiometabolic disease.Diabetologia · 2025Article
- Parity modifies the effect of genetic variants associated with gestational duration and birth weight.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Physical activity, fitness, and cardiac autonomic function among adults born postterm.American journal of epidemiology · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
74 authors at 20 institutions in 9 countries.
Xueping LiuDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Dorte HeleniusiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Line SkotteDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7398-1271
Robin N BeaumontInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0750-8248
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Julius JuodakisDepartment of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-5600-974X
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.ORCID http://orcid.org/0000-0001-5585-3420
Jonathan P BradfieldCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Frederick T J LinDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1670-6086
Suzanne VogelezangThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Mariona BustamanteISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Tarunveer S AhluwaliaCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7464-3354
Niina PitkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.
Carol A WangSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, NSW, Australia.ORCID http://orcid.org/0000-0002-4301-3974
Jonas BacelisDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-2450-732X
Maria C BorgesMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Ge ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Bruce A BedellDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Robert M RossiMarch of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
Kristin SkogstrandiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0026-3711
Shouneng PengDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
Wesley K ThompsoniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Vivek AppaduraiiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Debbie A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6793-2262
Ilkka KallialaDepartment of Surgery and Cancer, IRDB, Faculty of Medicine, Imperial College, London, W12 0NN, UK.ORCID http://orcid.org/0000-0002-7664-0587
Christine PowerPopulation, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.
Mark I McCarthyWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.ORCID http://orcid.org/0000-0002-4393-0510
Heather A BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6849-9985
Mary L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral Biology School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Hakon HakonarsonCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2814-7461
M Geoffrey HayesDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Denise M ScholtensDivision of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Fernando RivadeneiraThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Rebecca K VindingCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4131-7592
Bridget A KnightNIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0002-2073-0487
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.
Øyvind HelgelandK. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-5612-2985
Stefan JohanssonK. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-2298-7008
Pål R NjølstadK. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-0304-6728
João FadistaDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Andrew J SchorkiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Ron NudeliPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-2309-011X
Daniel E MillerCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Xiaoting ChenCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Matthew T WeirauchDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-7977-9122
Preben Bo MortenseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-8627-7219
Merete NordentoftiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
Kelli K RyckmanDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
David M HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Leah C KottyanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-3979-2220
Craig E PennellSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, NSW, Australia.
Leo-Pekka LyytikainenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2003-1018
Martine VrijheidISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
William L LoweDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Struan F A GrantCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2025-5302
Elina HyppönenPopulation, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0003-3670-9399
Bo JacobssonDepartment of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-5079-2374
Marjo-Riitta JarvelinInstitute of Health Sciences, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0002-2149-0630
Louis J MugliaDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-0301-8770
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Rachel M FreathyInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-4152-2238
Thomas M WergeiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1829-0766
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8264-6785
Alfonso BuiliPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-1863-164X
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. fee@ssi.dk.ORCID http://orcid.org/0000-0003-1478-649X
Statens Serum Institut · DKMental Health Services · DKUniversity of Copenhagen · DKCincinnati Children's Hospital Medical Center · USErasmus MC · NLNorthwestern University · USUniversity of Iowa · USChildren's Hospital of Philadelphia · USUniversity of Exeter · GBUniversity of Turku · FIAarhus University · DKCentre for Human Genetics · GBHaukeland University Hospital · NOIcahn School of Medicine at Mount Sinai · USImperial College London · GBNorwegian Institute of Public Health · NOUniversitat Pompeu Fabra · ESUniversity of Bristol · GBUniversity of Newcastle Australia · AUAarhus University Hospital · DK
Funding
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Grant Sanford Schulert · 2016 to 2026
$7.7MBIOCHEMICAL AND GENETIC ANALYSIS OF NOTCH SIGNALINGR01GM055479 · NIGMS · WASHINGTON UNIVERSITY · PI KOPAN, RAPHAEL, WEIRAUCH, MATTHEW TYSON · 1996 to 2021
$6.4MBinding of Epstein Barr Virus EBNA2 Unifies Multiple Sclerosis Genetic MechanismsR01NS099068 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan, Matthew Tyson Weirauch · 2017 to 2026
$4.2MHarnessing "omics": A Systems Biology approach to discovery of biologicalpathways in placental development and parturitionR01HD091527 · NICHD · UNIVERSITY OF FLORIDA · PI BALONI, PRIYANKA, JONES, HELEN N · 2017 to 2021
$2.7MMetabolomic and Epigenomic Mechanisms in Developmental Overnutrition.R01DK103246 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2014 to 2018
$2.2MIntegrating genome-scale data to reveal causal mechanisms in type 2 diabetesU01DK105535 · NIDDK · UNIVERSITY OF OXFORD · PI GLOYN, ANNA LOUISE · 2015 to 2019
$1.7MMedical Research Council MC_UU_00011/6NIAMS NIH HHS P30 AR070549NICHD NIH HHS R01 HD091527NIDDK NIH HHS R01 DK103246NIDDK NIH HHS U01 DK105535NIGMS NIH HHS R01 GM055479NINDS NIH HHS R01 NS099068Wellcome Trust 090532Wellcome Trust 093831Wellcome Trust 106130Wellcome Trust 203141
Abstract
The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10
Indexed as
Polymorphism, Single NucleotideChromosomes, Human, Pair 2CytokinesFemaleFetusGenome, HumanGenome-Wide Association StudyGestational AgeHumansInfant, NewbornPregnancyPremature BirthCytokines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.