ArticleNature communications2019
CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- A chromatin-linked CPL2-PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- DNA methylation in plant heterosis: mechanisms and prospects.Functional & integrative genomics · 2025Review
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Molecular Mechanisms Underlying the Establishment, Maintenance, and Removal of DNA Methylation in Plants.Annual review of plant biology · 2025Review
- CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing.Nature communications · 2024Article
- Article
- H1 restricts euchromatin-associated methylation pathways from heterochromatic encroachment.eLife · 2024Article
- Identification of epigenetically regulated genes involved in plant-virus interaction and their role in virus-triggered induced resistance.BMC plant biology · 2024Article
- Emerging Roles of Epigenetics in Grapevine and Winegrowing.Plants (Basel, Switzerland) · 2024Review
- Article
- The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.Nature communications · 2023Article
- DDM1-Mediated TE Silencing in Plants.Plants (Basel, Switzerland) · 2023Review
- The MOM1 complex recruits the RdDM machinery via MORC6 to establishbioRxiv : the preprint server for biology · 2023Article
- Quantitative analysis of protein dynamics using a deep learning technique combined with experimental cryo-EM density data and MD simulations.Biophysics and physicobiology · 2023Article
- BPM1 regulates RdDM-mediated DNA methylation via a cullin 3 independent mechanism.Plant cell reports · 2022Article
- Linking transcriptional silencing with chromatin remodeling, folding, and positioning in the nucleus.Current opinion in plant biology · 2022Review
- Comprehensive identification of SWI/SNF complex subunits underpins deep eukaryotic ancestry and reveals new plant components.Communications biology · 2022Article
- Regulatory mechanism of a heat-activated retrotransposon by DDR complex inFrontiers in plant science · 2022Article
- Article
- The RNA Directed DNA Methylation (RdDM) Pathway Regulates Anthocyanin Biosynthesis in Crabapple (Plants (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
Transcription by RNA polymerase V (Pol V) in plants is required for RNA-directed DNA methylation, leading to transcriptional gene silencing. Global chromatin association of Pol V requires components of the DDR complex DRD1, DMS3 and RDM1, but the assembly process of this complex and the underlying mechanism for Pol V recruitment remain unknown. Here we show that all DDR complex components co-localize with Pol V, and we report the cryoEM structures of two complexes associated with Pol V recruitment-DR (DMS3-RDM1) and DDR' (DMS3-RDM1-DRD1 peptide), at 3.6 Å and 3.5 Å resolution, respectively. RDM1 dimerization at the center frames the assembly of the entire complex and mediates interactions between DMS3 and DRD1 with a stoichiometry of 1 DRD1:4 DMS3:2 RDM1. DRD1 binding to the DR complex induces a drastic movement of a DMS3 coiled-coil helix bundle. We hypothesize that both complexes are functional intermediates that mediate Pol V recruitment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.