Trial reportTranslational psychiatry2019
Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression.
Trial report in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood.Scientific reports · 2021Trial
- Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences.European child & adolescent psychiatry · 2025Article
- The association between temperament and polygenic score for psychopathology from infancy to middle childhood.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Interplay between polygenic risk and family processes in predicting trajectories of adolescent externalizing behaviors.Frontiers in psychiatry · 2025Article
- Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.Development and psychopathology · 2024Article
- Predicting child aggression: The role of parent and child endorsement of reactive aggression across 13 cultural groups in 9 nations.Aggressive behavior · 2023Article
- A gene-environment cascade theoretical framework of developmental psychopathology.Journal of psychopathology and clinical science · 2023Article
- Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis.Molecular psychiatry · 2022Article
- Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression.Child psychiatry and human development · 2022Article
- Predicting mortality among ischemic stroke patients using pathways-derived polygenic risk scores.Scientific reports · 2022Article
- Characteristic of Molecular Subtypes in Lung Squamous Cell Carcinoma Based on Autophagy-Related Genes and Tumor Microenvironment Infiltration.Journal of oncology · 2022Article
- Polygenic Risk for Aggression Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood and is Moderated by a Family-Centered Intervention.Behavior genetics · 2021Article
- Analysis framework and experimental design for evaluating synergy-driving gene expression.Nature protocols · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression in a second, longitudinal sample of children (n = 515, 49% female) in early childhood (2-5 years old), and middle childhood (7.5-10.5 years old). Functional PRSs were associated with aggression in both the early and middle childhood models.
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