ReviewThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2019
Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression.
Review in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Trial
- The Effects of Gait Speed and Psychomotor Speed on Risk for Depression and Anxiety in Older Adults with Medical Comorbidities.Journal of the American Geriatrics Society · 2021Trial
- Preliminary Evidence That Cortical Amyloid Burden Predicts Poor Response to Antidepressant Medication Treatment in Cognitively Intact Individuals With Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Disrupted Large-Scale Brain Network Connectivity in Prolonged Grief Disorder: Relationship With Grief-Related Avoidance, Yearning, and Intrusive Thoughts.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross-sectional study.Psychiatry and clinical neurosciences · 2026Article
- Synaptic Plasticity-Intrinsic Excitability and Antidepressant Discovery.Biomedicines · 2026Review
- Longitudinal Changes in White Matter Hypointensities in Recurrent Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Right anterior supramarginal gyrus-cerebellum hyperconnectivity and rumination partially mediate the link between childhood abuse and anger in late-life depression.Journal of affective disorders · 2026Article
- Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Advances in experimental medicine and biology · 2026Review
- Stress and emotional wellbeing among LGBT older adults: a moderated mediation model for social network size, composition, and perceived social support.The Gerontologist · 2025Article
- Dose-Response Associations of Grip Strength and Gait Speed With Multidimensional Mental Health.Aging medicine (Milton (N.S.W)) · 2025Article
- Network homeostasis: functional brain network alterations and relapse in remitted late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- White matter hyperintensities and relapse risk in late-life depression.Journal of affective disorders · 2025Article
- Brain and cardiovascular responses to acute stress in remitted and recurrent late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy.Biomedicines · 2025Review
- Brain Age Is Not a Significant Predictor of Relapse Risk in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Reconsidering remission in recurrent late-life depression: clinical presentation and phenotypic predictors of relapse following successful antidepressant treatment.Psychological medicine · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
The significant public health burden associated with late-life depression (LLD) is magnified by the high rates of recurrence. In this manuscript, we review what is known about recurrence risk factors, conceptualize recurrence within a model of homeostatic disequilibrium, and discuss the potential significance and challenges of new research into LLD recurrence. The proposed model is anchored in the allostatic load theory of stress. We review the allostatic response characterized by neural changes in network function and connectivity and physiologic changes in the hypothalamic-pituitary-adrenal axis, autonomic nervous system, immune system, and circadian rhythm. We discuss the role of neural networks' instability following treatment response as a source of downstream disequilibrium, triggering and/or amplifying abnormal stress response, cognitive dysfunction and behavioral changes, ultimately precipitating a full-blown recurrent episode of depression. We propose strategies to identify and capture early change points that signal recurrence risk through mobile technology to collect ecologically measured symptoms, accompanied by automated algorithms that monitor for state shifts (persistent worsening) and variance shifts (increased variability) relative to a patient's baseline. Identifying such change points in relevant sensor data could potentially provide an automated tool that could alert clinicians to at-risk individuals or relevant symptom changes even in a large practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.