ArticlePlacenta2019
Preterm birth subtypes, placental pathology findings, and risk of neurodevelopmental disabilities during childhood.
Article in Placenta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Examining the association between placental malperfusion assessed by histopathological examination and child and adolescent neurodevelopment: a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Maternal bioactive lipids during pregnancy and early childhood neurodevelopment and behavior.Pediatric research · 2026Article
- Maternal Poly (I:C)-Induced Placental Inflammation and Endocrine Dysfunction Are Associated with Disrupted Corticogenesis in Mouse Offspring.Brain sciences · 2026Article
- From etiology to outcome: investigating the link between placental pathology and clinical risk for preterm birth and neurodevelopment.Pediatric research · 2025Article
- Placental and cord serum inflammatory cytokines and children's domain-specific neurodevelopment at 18 months: effect modification by maternal vitamin D status.BMC medicine · 2025Article
- Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders.Communications biology · 2025Article
- Early Life Origins of Neurodevelopmental Disabilities in the Boston Birth Cohort: Research findings and future directions.Precision nutrition · 2024Article
- Impact of maternal infection on outcomes in extremely preterm infants.Pediatric research · 2024Article
- Independent and joint association of cord plasma pantothenate and cysteine levels with autism spectrum disorders and other neurodevelopmental disabilities in children born term and preterm.Precision nutrition · 2023Article
- The Association of Placental Abruption and Pediatric Neurological Outcome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Boston Birth Cohort profile: rationale and study design.Precision nutrition · 2022Article
- Defective Placentation Syndromes and Intellectual Disability in the Offspring: Nationwide Cohort and Sibling-Controlled Studies.American journal of epidemiology · 2022Article
- Defective placentation syndromes and autism spectrum disorder in the offspring: population-based cohort and sibling-controlled studies.European journal of epidemiology · 2022Article
- Placental morphology in association with autism-related traits in the EARLI study.BMC pregnancy and childbirth · 2022Article
- What is known about neuroplacentology in fetal growth restriction and in preterm infants: A narrative review of literature.Frontiers in endocrinology · 2022Review
- Development of the genomic inflammatory index (GII) to assess key maternal antecedents associated with placental inflammation.Placenta · 2021Article
- Amniotic fluid interleukin 6 and interleukin 8 are superior predictors of fetal lung injury compared with maternal or fetal plasma cytokines or placental histopathology in a nonhuman primate model.American journal of obstetrics and gynecology · 2021Article
- Autism spectrum disorders in extremely preterm infants and placental pathology findings: a matched case-control study.Pediatric research · 2021Article
- Placental Histopathology and Pregnancy Outcomes in "Early" vs. "Late" Placental Abruption.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Placental origins of neonatal diseases: toward a precision medicine approach.Pediatric research · 2021Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
introductionPreterm birth (PTB) and in-utero inflammation are recognized risk factors of neurodevelopmental disabilities (NDDs); however, their combined role in NDDs is unknown. We examined the independent and joint association of PTB and placental histological findings with the childhood risk of NDDs (overall and by subgroups including autism spectrum disorder (ASD) and ADHD).
methodsWe analyzed data from the Boston Birth Cohort, where mother-infant pairs were enrolled at birth and followed from birth onwards. Birth outcomes, placental pathology and NDDs were obtained from electronic medical records. Placental pathology was categorized using a standardized classification system proposed by the Amsterdam Placental Workshop Group.
resultsPTB (all, including spontaneous, medically indicated) was an independent risk factor for NDDs. Placental histological chorioamnionitis (CA) and PTB additively increased the odds of NDDs (aOR: 2.16, 95% CI: 1.37, 3.39), as well as ADHD (aOR: 2.75, 95% CI: 1.55, 4.90), other developmental disabilities (aOR: 1.96, 95% CI: 1.18, 3.25) and possibly ASD (aOR: 2.31, 95% CI: 0.99, 5.39). The above associations were more pronounced in spontaneous than medically indicated PTB. PTB alone in the absence of CA only had a moderate association with ASD and ADHD. Placental maternal vascular malperfusion alone or in combination with PTB was not associated with the risk of NDDs. DISCUSSION: Our study provided new insights on PTB and NDDs by further considering preterm subtypes and placental histology. We revealed that children of spontaneous PTB along with histological CA were at the highest risk for a spectrum of NDDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.