ArticlePsychological medicine2020
Deep phenotyping of attention impairments and the 'Inattention Biotype' in Major Depressive Disorder.
Article in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Predicting Repetitive Negative Thinking in Daily Life: Insights From Brain-Based Graph-Theoretical Predictive Modeling.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Neural Circuit Taxonomy and Precision Psychiatry in Major Depression.Advances in experimental medicine and biology · 2026Review
- Interactions Between Depression, Autonomic Dysfunction, Inhibitory Control and Reaction Time: Insights From Heart Rate Variability During Continuous Performance Test.Psychiatry investigation · 2025Article
- Reproducible sex differences in personalised functional network topography in youth.The British journal of psychiatry : the journal of mental science · 2025Article
- Differences in cognitive deficits and brain functional impairments between patients with first-episode and recurrent depression.BMC psychiatry · 2025Article
- Brain Circuit-Derived Biotypes for Treatment Selection in Mood Disorders: A Critical Review and Illustration of a Functional Neuroimaging Tool for Clinical Translation.Biological psychiatry · 2024Review
- Reproducible Sex Differences in Personalized Functional Network Topography in Youth.bioRxiv : the preprint server for biology · 2024Article
- Analysis of functional connectivity changes in attention networks and default mode networks in patients with depression and insomnia.Sleep & breathing = Schlaf & Atmung · 2024Article
- Resting-State Alpha Activity in the Frontal and Occipital Lobes and Assessment of Cognitive Impairment in Depression Patients.Psychology research and behavior management · 2024Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- Personalized functional brain network topography is associated with individual differences in youth cognition.Nature communications · 2023Article
- Depressive states in healthy subjects lead to biased processing in frontal-parietal ERPs during emotional stimuli.Scientific reports · 2023Article
- Mapping the relationship of white matter lesions to depression in multiple sclerosis.medRxiv : the preprint server for health sciences · 2023Article
- Behavioral and biologic characteristics of cancer-related cognitive impairment biotypes.Brain imaging and behavior · 2023Article
- Hierarchical functional system development supports executive function.Trends in cognitive sciences · 2023Review
- Issues and opportunities of digital phenotyping: ecological momentary assessment and behavioral sensing in protecting the young from suicide.Frontiers in psychology · 2023Article
- Decomposing Working Memory in Recurrent Major Depression: Impaired Encoding and Limited Maintenance Immune-to-Encoding Constraint.Brain sciences · 2022Article
- The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research.Biomedicines · 2022Review
- Reduced neural responses to reward reflect anhedonia and inattention: an ERP study.Scientific reports · 2022Article
- Aberrant brain connectivity is associated with childhood maltreatment in individuals with major depressive disorder.Brain imaging and behavior · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundAttention impairment is an under-investigated feature and diagnostic criterion of Major Depressive Disorder (MDD) that is associated with poorer outcomes. Despite increasing knowledge regarding mechanisms of attention in healthy adults, we lack a detailed characterization of attention impairments and their neural signatures in MDD.
methodsHere, we focus on selective attention and advance a deep multi-modal characterization of these impairments in MDD, using data acquired from n = 1008 patients and n = 336 age- and sex-matched healthy controls. Selective attention impairments were operationalized and anchored in a behavioral performance measure, assessed within a battery of cognitive tests. We sought to establish the accompanying neural signature using independent measures of functional magnetic resonance imaging (15% of the sample) and electroencephalographic recordings of oscillatory neural activity.
resultsGreater impairment on the behavioral measure of selective attention was associated with intrinsic hypo-connectivity of the fronto-parietal attention network. Not only was this relationship specific to the fronto-parietal network unlike other large-scale networks; this hypo-connectivity was also specific to selective attention performance unlike other measures of cognition. Selective attention impairment was also associated with lower posterior alpha (8-13 Hz) power at rest and was related to more severe negative bias (frequent misidentifications of neutral faces as sad and lingering attention on sad faces), relevant to clinical features of negative attributions and brooding. Selective attention impairments were independent of overall depression severity and of worrying or sleep problems.
conclusionsThese results provide a foundation for the clinical translational development of objective markers and targeted therapeutics for attention impairment in MDD.
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