Evidence map›Paper›PMID 31477184›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2019

Survival outcomes of marijuana users in p16 positive oropharynx cancer patients.

Han Zhang, Michael Xie, Marc Levin, Stuart D Archibald, B Stanley Jackson, J E M Young, Michael K Gupta

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Role of Cannabinoids in Oral Cancer.International journal of molecular sciences · 2024
    Review
  3. Cannabis related side effects in otolaryngology: a scoping review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Han ZhangDivision of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada.
Michael XieMichael DeGroote Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada.
Marc LevinMichael DeGroote Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada.
Stuart D ArchibaldMichael DeGroote Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada.
B Stanley JacksonDivision of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada.
J E M YoungDivision of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada.
Michael K GuptaDivision of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada. michaelkgupta@hotmail.com.ORCID http://orcid.org/0000-0002-1075-2893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have suggested an association between marijuana use and HPV-related OPSCC. Despite this, no study has examined the potential relationship between marijuana use and survival in this subset of patients.

objectiveTo examine the survival outcomes of HPV-related OPSCC patients in marijuana users.

methodsPatients who were marijuana users were identified from a prospectively collected database of HNC patients from January 2011 to 2015. A physical review of clinic records was undertaken to extract relevant patient, tumor, treatment, follow-up, as well as survival data. Patients greater than 17 years of age with pathologically proven p16 positive OPSCC were included. They were then case-matched in a 1-to-1 basis to patients who were non-marijuana users based on age, gender, and cTNM staging.

resultsForty-Seven patients met inclusion criteria within each group. Univariate logistic regression analysis showed that age, gender, and cT-Stage were predictive of disease recurrence within both groups (p < 0.05). However, cN-stage, treatment modality, tumor subsite, tobacco use, and tobacco dose were not (p > 0.05). There was no statistically significant difference between marijuana and non-marijuana user groups in 5-year (p = 0.400) overall survival, disease-specific (p = 0.993), disease-free (p = 0.404), and metastasis-free survival (p = 0.384).

conclusionsNo survival difference is found between HPV-related OPSCC marijuana users and non-users. This finding has implications for both de-escalation regimes and the use of cannabis as a therapeutic agent.

Indexed as

Marijuana UseAdolescentAdultAgedAged, 80 and overCarcinoma, Squamous CellFemaleFollow-Up StudiesHuman papillomavirus 16HumansMaleMiddle AgedOropharyngeal NeoplasmsPapillomavirus InfectionsSurvival AnalysisYoung AdultMarijuanap16 positive oropharyngeal cancerSurvival outcomes

Identifiers

PMID31477184
PMCPMC6720071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.