ArticleGenome biology2019
Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.
Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Genome sequencing and multi-stage, blood-feeding, and tissue-specific transcriptome atlas of the Rocky Mountain wood tick provide a critical resource for this vector.Insect biochemistry and molecular biology · 2026Article
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- Visual adaptation of a biting fly that permanently foregoes flight.The Journal of experimental biology · 2026Article
- PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies.PLoS pathogens · 2026Article
- Genome sequencing and multi-stage, blood-feeding, and tissue-specific transcriptome atlas of the Rocky Mountain wood tick provide a critical resource for this vector.bioRxiv : the preprint server for biology · 2026Article
- Bridging behaviour and genomics for tsetse fly control.Nature reviews. Genetics · 2026Article
- Insect immune systems: same same but different but still same.Frontiers in immunology · 2026Review
- New tsetse (Glossina fuscipes fuscipes) genomes generated from wild and laboratory-reared specimens.Insect science · 2025Article
- Developing targets to control multiple pest fly species: violet polyester targets effectively attract tsetse (Diptera: Glossinidae), stable flies (Diptera: Muscidae), and house flies (Diptera: Muscidae).Journal of economic entomology · 2025Article
- The genome of the American dog tick (Dermacentor variabilis).G3 (Bethesda, Md.) · 2025Article
- Viviparity and obligate blood feeding: tsetse flies as a unique research system to study climate change.Current opinion in insect science · 2025Review
- The Genome of the American Dog Tick (bioRxiv : the preprint server for biology · 2025Article
- Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes.PLoS pathogens · 2025Article
- mir-31 mediated control of bacteriome size in tsetse flies.Current research in insect science · 2025Article
- An Overview of Tsetse Fly Repellents: Identification and Applications.Journal of chemical ecology · 2024Review
- Article
- Immune Reactions of Vector Insects to Parasites and Pathogens.Microorganisms · 2024Review
- Chromosome-level genome of the poultry shaft louse Menopon gallinae provides insight into the host-switching and adaptive evolution of parasitic lice.GigaScience · 2024Article
- Diaci v3.0: chromosome-level assembly, de novo transcriptome, and manual annotation of Diaphorina citri, insect vector of Huanglongbing.GigaScience · 2024Article
- Annotation of transposable elements in the transcriptome of the Neotropical brown stink bug Euschistus heros and its chromosomal distribution.Molecular genetics and genomics : MGG · 2023Article
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Authors and funding
54 authors.
Funding
Abstract
backgroundTsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity.
resultsGenomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges.
conclusionsExpanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.
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