Evidence map›Paper›PMID 31477126›Full record

ArticleParticle and fibre toxicology2019

Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration.

Mohamed Abdelgied, Ahmed M El-Gazzar, William T Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno and 5 more

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Mohamed AbdelgiedNanotoxicology Project, Nagoya City University, 3-1 Tanabe-Dohri, Mizuho-ku, Nagoya, 466- 8603, Japan.
Ahmed M El-GazzarNanotoxicology Project, Nagoya City University, 3-1 Tanabe-Dohri, Mizuho-ku, Nagoya, 466- 8603, Japan.
William T AlexanderNanotoxicology Project, Nagoya City University, 3-1 Tanabe-Dohri, Mizuho-ku, Nagoya, 466- 8603, Japan.
Takamasa NumanoNanotoxicology Project, Nagoya City University, 3-1 Tanabe-Dohri, Mizuho-ku, Nagoya, 466- 8603, Japan.
Masaaki IigouNanotoxicology Project, Nagoya City University, 3-1 Tanabe-Dohri, Mizuho-ku, Nagoya, 466- 8603, Japan.
Aya Naiki-ItoDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hiroshi TakaseCore Laboratory, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Akihiko HiroseDivision of Risk Assessment, National Institute of Health Sciences, Kawasaki, Japan.
Yuhji TaquahashiDivision of Cellular and Molecular Toxicology, National Institute of Health Sciences, Kawasaki, Japan.
Jun KannoJapan Industrial Safety and Health Association, Japan Bioassay Research Center, Kanagawa, Japan.
Mona AbdelhamidDepartment of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Khaled Abbas AbdouDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt.
Satoru TakahashiDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
David B AlexanderNanotoxicology Project, Nagoya City University, 3-1 Tanabe-Dohri, Mizuho-ku, Nagoya, 466- 8603, Japan. dalexand@phar.nagoya-cu.ac.jp.ORCID 0000-0002-9017-3639
Hiroyuki TsudaNanotoxicology Project, Nagoya City University, 3-1 Tanabe-Dohri, Mizuho-ku, Nagoya, 466- 8603, Japan. htsuda@phar.nagoya-cu.ac.jp.
Nagoya City University · JPBeni-Suef University · EGNational Institute of Health Sciences · JPJapan Industrial Safety and Health Association · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPotassium octatitanate fibers (K

resultsThere were no differences between the r-nTiO

conclusionThe incidence of pleural mesotheliomas in male F344 rats administered POT fibers and MWCNT-7 was significantly higher than the JBRC historical control data, indicating that the incidence of pleural mesothelioma in the groups administered POT fibers and MWCNT-7 fibers via the airway using TIPS was biologically significant. The incidence of type II epithelial cell hyperplasia and the histology of the carcinomas that developed in the POT treated rats also indicates that respirable POT fibers are highly likely to be carcinogenic in the lungs of male F344 rats.

Indexed as

AnimalsCarcinogensInhalation ExposureLungLung NeoplasmsMaleMesotheliomaMesothelioma, MalignantMineral FibersPleuraRats, Inbred F344Surface PropertiesTissue DistributionTitaniumCarcinogensMineral Fiberspotassium octatitanateTitaniumIntra-tracheal intra-pulmonary sprayingLung carcinomaMalignant mesotheliomaMWCNT-7Potassium octatitanate fibersTIPS

Identifiers

PMID31477126
PMCPMC6720102
OpenAlexW2972052796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.