SynthesisBMC ophthalmology2019
Efficacy and safety of extended depth of focus intraocular lenses in cataract surgery: a systematic review and meta-analysis.
Synthesis in BMC ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05335408 (A Randomized Controlled Trial on the Visual Function After Bilateral Implantation of Two Novel Extended Depth-of-Focus Intraocular Lenses), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial on the Visual Function After Bilateral Implantation of Two Novel Extended Depth-of-Focus Intraocular Lenses
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative efficacy and safety of all kinds of intraocular lenses in presbyopia-correcting cataract surgery: a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Comparison of trifocal or hybrid multifocal-extended depth of focus intraocular lenses: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Evaluating the effects of trifocals and extended depth of focus intraocular lens implantation on stereopsis and contrast sensitivity in cataract patients.Indian journal of ophthalmology · 2026Trial
- Influence of isofocal intraocular lenses on objective refraction based on autorefraction and aberrometry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Trial
- Prospective Randomized Single-Masked Study of Bilateral Isofocal Optic-Design or Monofocal Intraocular Lenses.Clinical ophthalmology (Auckland, N.Z.) · 2023Trial
- Clinical Outcomes after Bilateral Mix-and-Match Implantation of Extended Depth of Focus and Trifocal Intraocular Lenses.Korean journal of ophthalmology : KJO · 2026Article
- Visual Outcomes Three and Six Months After Bilateral Implantation of Extended Monofocal Isopure 1.2.3 Lenses.Journal of clinical medicine · 2026Article
- Visual outcomes in patients with bilateral early to moderate primary open-angle glaucoma following wavefront-shaping partial-range of field-extend intraocular lens implantation.The British journal of ophthalmology · 2026Article
- One-piece extended depth of focus intraocular lens implantation in the capsular bag in the presence of a posterior capsule rupture.International journal of surgery case reports · 2026Article
- Comparative Photopic and Mesopic Visual Performance of Enhanced Monofocal Versus Non-Diffractive Extended Depth-of-Focus Intraocular Lenses.Journal of clinical medicine · 2026Article
- The Science of Pseudoaccommodation and Its Therapeutic Potential.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Outcomes of Extended Monofocal and Extended Depth of Focus Intraocular Lens Implantation by a Trainee Surgeon in an Australian Tertiary Public Hospital.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- [Evidence-based approach for premium intraocular lenses: management of postoperative dissatisfaction].Die Ophthalmologie · 2025Review
- Visual Quality and Symptomatology Following Implantation of a Non-Diffractive Extended Depth-of-Focus Intraocular Lens.Journal of clinical medicine · 2025Article
- Patient satisfaction and quality of vision after bilateral implantation of enhanced monofocal IOL and mini-monovision: a prospective study.Eye and vision (London, England) · 2025Article
- Visual Results After Extended Depth-of-Focus Lens Implantation in Patients Undergoing Clear Lens Surgery.Journal of clinical medicine · 2025Article
- Patient-reported Outcome Measures for Assessing Spectacle Independence after Implantation of Monofocal or Extended Depth of Focus (EDOF) Intraocular Lenses with Various Degrees of Monovision.Klinische Monatsblatter fur Augenheilkunde · 2025Article
- Objective Depth-of-Focus Estimation from Wavefront Measurements After Implantation of an Isofocal Intraocular Lens.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients.Journal of ophthalmic & vision research · 2025Article
- Visual outcomes with a non-diffractive enhanced depth-of-focus IOL in patients with age-related macular degeneration.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundThis study aims to evaluate the efficacy and safety of extended depth of focus (EDOF) intraocular lenes (IOLs) in cataract surgery.
methodsAll comparative clinical trials that involved bilaterally implanting EDOF IOLs in patients with cataract were retrieved from the literature database. We used random effects models to pool weighted mean differences (WMD) and risk ratio (RR) for continuous and dichotomous variables, respectively.
resultsNine studies with a total of 1336 eyes were identified. The subgroup analysis was conducted according to the type of IOLs used in the control group. Compared with monofocal IOLs, EDOF IOLs produced better uncorrected intermediate visual acuity (WMD: -0.17, 95% CI: - 0.26 to - 0.08, P = 0.0001) and uncorrected near visual acuity (WMD: -0.17, 95% CI: - 0.21 to - 0.12, P < 0.00001). EDOF IOLs resulted in reduced contrast sensitivity, more frequent halos, however, higher spectacle independence (RR: 2.81, 95% CI: 1.06 to 7.46, P = 0.04) than monofocal IOLs. Compared with trifocal IOLs, EDOF IOLs produced worse near visual acuity (MD: 0.10, 95% CI: 0.07 to 0.13, P < 0.0001). EDOF IOLs performed better than trifocal IOls in contrast sensitivity, and there were no significant difference in halos and spectacle independence. Serious postoperative complications were rare, with no adverse events were reported in most studies.
conclusionsIncreasing the risk of contrast reduction and more frequent halos, EDOF IOLs provided better intermediate and near VAs than monofocal IOLs. At the expense of near vision, patients receiving EDOF IOLs have better contrast sensitivity than those receiving trifocal IOLs. Halo incidence and spectacle independence of EDOF IOLs were similar to those of trifocal IOLs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.