Evidence map›Paper›PMID 31477040›Full record

ArticleBMC nephrology2019

The relation between dialysis-requiring acute kidney injury and recovery from end-stage renal disease: a national study.

Zijin Chen, Benjamin J Lee, Charles E McCulloch, Nilka Ríos Burrows, Michael Heung, Raymond K Hsu, Meda E Pavkov, Neil R Powe, Rajiv Saran, Vahakn Shahinian and 2 more

Abstract read
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zijin ChenDivision of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Benjamin J LeeDivision of Nephrology, Department of Medicine, University of California, San Francisco, 533 Parnassus Ave, U404, Box 0532, San Francisco, CA, 94143-0532, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Nilka Ríos BurrowsDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Michael HeungDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
Raymond K HsuDivision of Nephrology, Department of Medicine, University of California, San Francisco, 533 Parnassus Ave, U404, Box 0532, San Francisco, CA, 94143-0532, USA.
Meda E PavkovDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Neil R PoweUCSF Center for Vulnerable Populations, Department of Medicine, University of California, San Francisco, CA, USA.
Rajiv SaranDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
Vahakn ShahinianDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
Chi-Yuan HsuDivision of Nephrology, Department of Medicine, University of California, San Francisco, 533 Parnassus Ave, U404, Box 0532, San Francisco, CA, 94143-0532, USA. chi-yuan.hsu@ucsf.edu.
Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team

Funding

Acute kidney injury among patients with chronic kidney diseaseR01DK114014 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 2018 to 2021
$3.0M
Patient Oriented Research in Kidney DiseaseK24DK092291 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 2011 to 2020
$1.2M
Enhancing appreciation of the clinical significance of acute kidney injuryK23DK100468 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, RAYMOND · 2013 to 2017
$892k
Clinical Outcomes after Dialysis-Requiring Acute Kidney InjuryR03DK111881 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, RAYMOND · 2017 to 2018
$159k
Recovery after dialysis-requiring acute kidney injuryF32DK115030 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, BENJAMIN JIAWEI · 2017 to 2017
$79k
ACL HHS U18DP006255NCCDPHP CDC HHS U18 DP006255NIDDK NIH HHS F32 DK115030NIDDK NIH HHS K23 DK100468NIDDK NIH HHS K24 DK092291NIDDK NIH HHS R01 DK114014NIDDK NIH HHS R03 DK111881NIH HHS F32DK115030NIH HHS K24DK92291 and R01DK114014
6 · The paper itself

Abstract

backgroundApproximately 4-6% of incident end stage renal disease (ESRD) patients in the U.S. recover enough kidney function to discontinue dialysis but there is considerable geographic variation. We undertook this study to investigate whether state-level variations in renal recovery among incident ESRD patients correlated with state-level variations in incidence of acute kidney injury requiring dialysis (AKI-D).

methodsWe conducted a national cross-sectional ecological study at the state-level using data from State Inpatient Databases and U.S. Renal Data System. All hospital admissions and all ESRD patients in 18 US states (AZ, AR, CA, FL, IA, KY, MA, MD, MI, NJ, NM, NY, NV, OR, RI, SC, VT, and WA) were included. Correlation between AKI-D incidence and rate of renal recovery across states was determined using Pearson's r (overall and in subgroups). We also calculated partial correlations adjusted for sex and age.

resultsAKI-D incidence ranged from 99.0 per million population (pmp) in Vermont to 490.4 pmp in Nevada. Rate of renal recovery among incident ESRD patients ranged from 8.8 pmp in Massachusetts to 29.3 pmp in Florida. A positive correlation between AKI-D incidence and rate of renal recovery among incident ESRD patients at state level was found overall (unadjusted r = 0.67; p = 0.002) and in age, sex, and race subgroups. The overall correlation persisted after adjusting for age (adjusted r = 0.62; p < 0.001) and sex (adjusted r = 0.65; p < 0.001).

conclusionOur findings suggest that AKI-D incidence is an important driver of renal recovery rates among incident ESRD patients.

Indexed as

Acute Kidney InjuryAgedAged, 80 and overCross-Sectional StudiesFemaleHumansKidney Failure, ChronicMaleMiddle AgedRecovery of FunctionRenal DialysisUnited StatesAKI-DESRDRenal recovery

Identifiers

PMID31477040
PMCPMC6720077

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.