Evidence map›Paper›PMID 31477036›Full record

ArticleBMC medical genetics2019

Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population.

Laith N Al-Eitan, Doaa M Rababa'h, Mansour A Alghamdi, Rame H Khasawneh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Laith N Al-EitanDepartment of Applied Biological Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan. lneitan@just.edu.jo.ORCID 0000-0003-0064-0190
Doaa M Rababa'hDepartment of Applied Biological Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Mansour A AlghamdiCollege of Medicine, King Khalid University, Abha, Saudi Arabia.
Rame H KhasawnehDepartment of Hematopathology, King Hussein Medical Center (KHMC), Jordan Royal Medical Services (RMS), Amman, 11118, Jordan.
Jordan University of Science and Technology · JOKing Hussein Medical Center · JOKing Khalid University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSingle nucleotide polymorphisms (SNPs) in several CYP genes have been associated with altered breast cancer (BC) risk in different populations. Despite this, there is a dearth of information on the roles of these SNPs in Jordanian BC patients. Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population. In addition, this work investigates the association between selected BC prognostic factors and variants of the aforementioned CYP candidate genes.

methodsBlood samples were withdrawn from 221 BC patients and 218 healthy volunteers recruited from the Jordanian population. Genomic DNA was withdrawn and, after quantification and quality control, was genotyped using the Sequenom MassARRAY® system (iPLEX GOLD). Statistical analysis was then carried out to assess allelic and genotypic frequencies as well as genetic association between cases and controls.

resultsThe CYP19A1 SNP rs7176005 (p < 0.0045) and the CYP1A2 SNP rs762551 (p = 0.004) were significantly associated with BC risk. However, no such association was found for the screened SNPs of the CYP2C9, CYP1B1, CYP2C19 and CYP3A4 genes. Regarding the prognostic factors of BC, several of the screened SNPs were associated with different pathological and clinical features.

conclusionsCertain CYP genes, particularly CYP19A1 and CYP1A2, were associated with BC risk and development in the Jordanian population.

Indexed as

Genetic Association StudiesAdultAgedAged, 80 and overAromataseBreast NeoplasmsCohort StudiesCyclophilinsCytochrome P-450 CYP1A2Cytochrome P-450 CYP1B1Cytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9Cytochrome P-450 CYP3AFemaleGenetic Predisposition to DiseaseGenotypeAromataseCyclophilinsCYP19A1 protein, humanCYP1A2 protein, humanCYP1B1 protein, humanCYP2C19 protein, humanCYP2C9 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP1A2Cytochrome P-450 CYP1B1Cytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9Cytochrome P-450 CYP3APPIG protein, humanBreast cancerCYPCYP19A1CYP1APrognostic factors

Identifiers

PMID31477036
PMCPMC6720417
OpenAlexW2971661346

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.