ArticleThe journal of headache and pain2019
Structural changes of cerebellum and brainstem in migraine without aura.
Article in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.Frontiers in neurology · 2026Pooled it
- The 200 most influential publications in migraine research: a bibliometric mapping of the intellectual landscape.Frontiers in neurology · 2025Pooled it
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- Observational
- Altered locus coeruleus functional connectivity in migraine without aura based on resting-state functional magnetic resonance imaging.Journal of oral & facial pain and headache · 2026Article
- Diffusion tensor imaging in chronic tension-type headache.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Brain networks activated when aggravating baseline chronic pain of an individual with new daily persistent headache: a case study.BMC neurology · 2025Article
- Mapping the brain cell-specific regulatory architecture of migraine: a single-cell causal framework nominating inhibitory-neuronal BTBD16 and astrocytic RIMS1 as therapeutic targets.The journal of headache and pain · 2025Article
- A new vision of the role of the cerebellum in pain processing.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Effects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study.The journal of headache and pain · 2025Article
- Neural correlates of pain acceptance and the role of the cerebellum: Functional connectivity and anatomical differences in individuals with headaches versus matched controls.European journal of pain (London, England) · 2025Article
- White matter alterations in episodic migraine without aura patients assessed with diffusion MRI: effect of free water correction.The journal of headache and pain · 2025Article
- Morphometric Analysis of Neocortical and Infratentorial Structures: Genetic and Environmental Insights from a Twin Neuroanatomical Study.Medicina (Kaunas, Lithuania) · 2025Article
- Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume.Scientific reports · 2025Article
- Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis.Frontiers in neurology · 2025Article
- Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation.The journal of headache and pain · 2024Article
- Involvement of the cerebellum in structural connectivity enhancement in episodic migraine.The journal of headache and pain · 2024Article
- Two distinct neuroanatomical subtypes of migraine without aura revealed by heterogeneity through discriminative analysis.Brain imaging and behavior · 2023Article
- Article
- Volumetric Differences in Cerebellum and Brainstem in Patients with Migraine: A UK Biobank Study.Biomedicines · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIncreasing evidence has suggested that the cerebellum is associated with pain and migraine. In addition, the descending pain system of the brainstem is the major site of trigeminal pain processing and modulation and has been discussed as a main player in the pathophysiology of migraine. Cerebellar and brainstem structural changes associated with migraineurs remain to be further investigated.
methodsVoxel-based morphometry (VBM) (50 controls, 50 migraineurs without aura (MWoAs)) and diffusion tensor imaging (DTI) (46 controls, 46 MWoAs) were used to assess cerebellum and brainstem anatomical alterations associated with MWoAs. We utilized a spatially unbiased infratentorial template toolbox (SUIT) to perform cerebellum and brainstem optimized VBM and DTI analysis. We extracted the average diffusion values from a probabilistic cerebellar white matter atlas to investigate whether MWoAs exhibited microstructure alterations in the cerebellar peduncle tracts.
resultsMWoAs showed decreased fractional anisotropy (FA) in the vermis VI extending to the bilateral lobules V and VI of the cerebellum. We also found higher axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) in the right inferior cerebellum peduncle tract in MWoAs. MWoAs exhibited both reduced gray matter volume and increased AD, MD and RD in the spinal trigeminal nucleus (SpV).
conclusionMWoAs exhibited microstructural changes in the cerebellum and the local brainstem. These structural differences might contribute to dysfunction of the transmission and modulation of noxious information, trigeminal nociception, and conduction and integration of multimodal information in MWoAs. These findings further suggest involvement of the cerebellum and the brainstem in the pathology of migraine without aura.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.